Computer methods and programs in biomedicine
Apr 30, 2026
BACKGROUND AND OBJECTIVE: Deformable medical image registration is important for radiotherapy planning, respiratory motion analysis, and organ function assessment. In medical image sequences such as 4D CT, organ motion involves large displacements, l... read more
BACKGROUND: Research consistently shows that depression and suicidal ideation (SI) often cooccur. However, SI can arise without elevated depressive symptoms, suggesting that additional factors may also contribute. This study investigated the protecti... read more
Journal of molecular graphics & modelling
Apr 30, 2026
P21-activated kinase 1 (PAK1) is a key serine/threonine kinase involved in cytoskeletal remodeling, cell proliferation, and survival, and its aberrant activation has been strongly associated with tumorigenesis in multiple cancer types. Owing to its c... read more
Computer methods and programs in biomedicine
Apr 30, 2026
BACKGROUND AND OBJECTIVE: Multi-class brain tumor classification from magnetic resonance imaging must achieve high diagnostic accuracy while maintaining low inference latency and reliable confidence for real-time clinical deployment. High-capacity de... read more
AIM: CT-based radio-biomarkers could provide non-invasive insights into tumour biology to risk-stratify patients. One of the limitations is the laborious manual segmentation of regions-of-interest (ROI). We present a deep learning auto-segmentation p... read more
Artificial intelligence (AI) is transforming pediatric healthcare, offering novel opportunities for early diagnosis, personalized treatment, and more efficient clinical workflows. However, its integration into children's health faces significant chal... read more
PURPOSE: To develop and validate deep learning models for predicting keratoconus progression risk using multimodal imaging and clinical data, enabling risk-stratified patient monitoring. DESIGN: A retrospective cohort study with external validation. ... read more
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Apr 30, 2026
Clear cell renal cell carcinoma (ccRCC) is distinguished by the absence of definitive diagnostic markers and efficacious treatment modalities, factors that collectively contribute to its unfavorable clinical prognosis. The targeting of senescent cell... read more
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Apr 30, 2026
The poor prognosis of lung adenocarcinoma (LUAD) remains unimproved. This study aimed to identify lymph node metastasis (LNM)-related and cellular immunity-related prognostic genes in LUAD and propose novel strategies to improve its prognosis. LUAD-r... read more
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Apr 30, 2026
Steroid-induced osteonecrosis of the femoral head (SONFH) is a major cause of disability among young and middle-aged adults. However, current diagnosis relies primarily on imaging findings and clinical manifestations, as stable and reliable molecular... read more
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