Virtual molecular mapping systems such as MISO and GigaTIME introduce a potentially transformative primitive in computational pathology: translation of H\&E whole-slide images into biologically structured molecular representations, learned on paired ... read more
Second generation antiandrogens, such as enzalutamide, are commonly prescribed to treat advanced prostate cancer. However, enzalutamide resistant prostate cancer (ERPC) invariably develops with more aggressive features. Management of ERPC is extremel... read more
Natural image representations are distributed across many dimensions of visual cortex activity, but little is known about how the multidimensional structure of these representations evolves over time following stimulus onset. Here we examined the tem... read more
Artificial Intelligence (AI) is transforming therapeutic discovery by scoring a large set of promising candidates and prioritizing a shortlist for further investigation. Quantifying the reliability of AI scores and preventing false positives among se... read more
The integration of contextual information is crucial for coherent perception and cognition. The morphology and conductance properties of cortical pyramidal cells suggest that they operate as "two-point neurons" (TPNs), asymmetrically combining drivin... read more
Protein post-translational modifications (PTMs), particularly phosphorylation, serve as the primary molecular switches that orchestrate cellular signaling and drug response. While PTM dysregulation is a hallmark of cancer and neurodegeneration, the l... read more
Biomedical image segmentation is a fundamental problem in computational biomedicine that aims to precisely delineate anatomical and biological structures, tissue types, or pathological regions in biomedical images. Accurate segmentation is essential ... read more
Adaptive behaviors depend on predicting outcomes from sensory evidence. Dopamine neurons in the ventral tegmental area (VTA) broadcast reward-prediction signals that guide learning. Yet the principles functionally coordinating information flow from i... read more
Neuroimaging is essential for studying the human brain; however, the deep interdisciplinary expertise required imposes a very high threshold, limiting its broader clinical and scientific applications. We introduce NEURA, a large language model (LLM)-... read more
Classic findings from neuropsychology and animal studies established the hippocampus as a key substrate for rapid learning and episodic memory, with the dentate gyrus exhibiting extreme sparse coding. Sparse coding has long been hypothesized to enabl... read more
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