Yawning is a highly conserved behavior, yet its neural dynamics across arousal state transitions remain poorly understood. Classical reflex models fail to account for the precise timing of yawns during large-scale changes in brain network organizatio... read more
Gene regulatory network (GRN) inference is a key problem in systems biology that aims to identify transcription factor (TF)-target gene interactions from high-dimensional gene expression data, but it remains challenging due to limited labeled data, c... read more
The prefrontal cortex (PFC), a brain region critical for executive and cognitive functions, is characterized by its protracted maturation extending through adolescence until early adulthood. During adolescence, the PFC undergoes substantial rearrange... read more
Spatial transcriptomics (ST) is a cutting-edge technology that measures gene expression while preserving spatial context and generating pathology-grade tissue images. Although ST has enabled numerous discoveries and demonstrated a huge application po... read more
Objective - Social Determinants of Health (SDoH) are critical to patient care and population health. Despite their importance, SDoH information is frequently embedded within unstructured clinical text such as patient-reported information or social wo... read more
Background: Identification of metastasis status in non-small cell lung cancer (NSCLC) is a critical part of understanding disease prognosis, treatment courses, trial eligibility, and population-level cancer surveillance. However, metastasis record ar... read more
Heterogeneity in sporadic Parkinson's Disease (PD) is a critical problem that drives variable rates of progression and treatment response and complicates clinical trials. Access to large PD datasets that may help in clustering this heterogeneity is r... read more
BACKGROUND: Autism spectrum disorder (ASD) is marked by profound neurobiological heterogeneity, which drives inconsistent neuroimaging findings and impede the discovery of reliable biomarkers for precise diagnosis and phenotypic prediction. Although ... read more
Background: Emerging evidence suggests that the oral microbiome may contribute to aberrant gut immune responses in Inflammatory Bowel Disease (IBD). Methods: We performed a comprehensive, harmonised analysis of aggregated oral microbiome 16S rRNA dat... read more
Background and Objectives Preoperative prediction of functional outcomes in contrast-enhancing glioma could support surgical decision-making and patient counseling, yet most existing models incorporate histopathological or postoperative variables una... read more
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