Protein kinases are central targets in drug discovery, yet early-stage development of potent and selective inhibitors remains challenging due to high experimental costs and limited interpretability of large-scale screening data. Here, we present Deep... read more
BACKGROUND: Accurate pretreatment assessment of the extent of tumor invasion and status of cervical lymph node metastasis is essential for staging and treatment planning in HNSCC. Deep learning (DL) shows promise but is limited by methodological hete... read more
Nowadays, manipulating digital images has become very simple due to the availability of sophisticated image editing tools, making the authenticity verification of digital content increasingly challenging. The widespread use of such tools has raised s... read more
PURPOSE: The migration and fusion of osteoclast precursors (OCPs) are critical steps in osteoclastogenesis and require substantial energy. Although oxidative phosphorylation (OXPHOS) is generally considered the major pathway supplying energy for thes... read more
PurposeTo quantify how large language model (LLM) assistance influences otolaryngology residents' operative planning in a simulation-based setting.MethodsIn a within-subjects paired design, 13 otolaryngology residents (PGY1-4) completed 21 synthetic ... read more
Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single-nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhi... read more
Disability and rehabilitation. Assistive technology
Apr 29, 2026
PURPOSE: This review explores the applications and challenges of machine learning (ML) in Paralympic and adaptive sports, focusing on performance profiling, injury prediction, movement analysis, and assistive technology development. MATERIALS AND MET... read more
Physical chemistry chemical physics : PCCP
Apr 29, 2026
This investigation presents a comprehensive SCAPS-1D and machine-learning-assisted investigation of four environmentally benign double-perovskite solar cell architectures: Device I (Cs2BiAgI6/WS2/FTO), Device II (Sm2NiMnO6/WS2/FTO), Device III (Sm2Ni... read more
We present a computational workflow, the Conformal Sampling of Catalytic Processes (CSCP) approach, and its application to the case of heterogeneous hydrogenation/reduction of carbon dioxide (CO2) on copper and nickel catalysts. CO2 activation is of ... read more
The First International Consensus on the diagnosis and management of fibromuscular dysplasia is a landmark document. Since its publication in 2019, important research has been ongoing in the field. In this review, we address current clinical challeng... read more
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