Cardiotoxicity remains the leading driver of drug attrition; however, its prediction remains suboptimal when conventional hERG assays and animal models are used. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) offer a human-rel... read more
Understanding gene regulation is fundamental to plant improvement. However, the lack of plant-specific single-cell assay for transposase-accessible chromatin using sequencing (scATAC-seq) frameworks and cross-species databases has limited insights in... read more
The noise of Magnetic Resonance Imaging (MRI) poses challenges for Deep Learning (DL) when tumor boundaries are obscured, tumor location and appearance are complex due to overlap between tumor and non-tumor cells, and modality identification is diffi... read more
Drug delivery and translational research
Apr 28, 2026
Hygroscopicity is one of the critical material attributes (CMAs) of active pharmaceutical ingredients (APIs), and excessive hygroscopicity can adversely affect drug manufacturability, stability, and even therapeutic efficacy. Traditional experimental... read more
Technology and health care : official journal of the European Society for Engineering and Medicine
Apr 28, 2026
BackgroundAn accurate diagnosis of children's self-care problems significantly matters in the growth and development of children. However, various and extensive disorders make the self-care problems classification extremely complex and require much e... read more
Lipid nanoparticle (LNP) delivery of RNA therapeutics is constrained by poor tissue selectivity and off-target toxicity. Most high-throughput screening approaches have focused on single-target efficacy while overlooking off-target uptake. Here we rep... read more
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