Representation learning is an emerging paradigm for deriving phenotypes from complex measurements (e.g., imaging) for genetic discovery. However, the learning dynamics of deep neural networks, especially the evolution of representations during traini... read more
Motivation: Accurate prediction of functional sites from primary sequences is essential for elucidating biological mechanisms and advancing rational drug design. However, traditional sequence-based features areinherently unable to capture complex str... read more
Protein function prediction remains a central challenge in computational biology due to the extreme sparsity and long-tail distribution of Gene Ontology (GO) [1] annotations. Advances in protein language models enable the extraction of dense, fixed-l... read more
Background: Surgical phase recognition is a critical prerequisite for context-aware operating rooms and automated skill assessment. While artificial intelligence (AI) benchmarking has progressed for simpler procedures, applying surgical phase recogni... read more
Background: The rapid expansion of medical literature has led to substantial variability and frequent contradictions in study findings, making it increasingly difficult to distinguish meaningful signals from noise. Much of this variability arises fro... read more
Retinal fluids, detectable through optical coherence tomography (OCT), are key biomarkers for retinal diseases such as diabetic macular edema and age-related macular degeneration, guiding treatment decisions and monitoring response to therapy. Automa... read more
Standardized patients (SPs) are central to clinical communication training but are constrained by cost, scalability, and reliance on trained actors. We present AI standardized patients (AI-SPs), large language model-driven simulators governed by a th... read more
Background. Large language models (LLMs) are increasingly used by clinicians to generate executable code for pharmacokinetic (PK) simulation. Whether such code meets the accuracy standards of target-controlled infusion systems has not been systematic... read more
Background: Diabetic retinopathy (DR) is the leading cause of preventable blindness among working-age adults worldwide, yet screening coverage remains inadequate, particularly in low- and middle-income countries. Automated deep learning systems offer... read more
Objective: To test whether machine learning (ML) models trained on tidal breathing flow time series can discriminate between individuals with and without respiratory disease and predict lung function indices obtained from conventional pulmonary funct... read more
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