Anxiety is usually gauged by self-report, yet a single symptom level can reflect disparate neural circuitry. In Alzheimer's disease and related dementias (ADRD) this heterogeneity becomes a barrier to effective neuromodulation: some patients may bene... read more
Purpose: To develop an interpretable feature-based Deep Parametric Response Mapping (PRMD) method that combines wavelet scattering convolution networks and machine learning to spatially detect and quantify functional small airways disease (fSAD) and ... read more
Background. Foundation models for electronic health records (EHRs) perform strongly on clinical prediction, but every published model has been trained within a single health system. No multi-institutional EHR foundation model currently exists, largel... read more
Background Although Kenya's HIV programme has long prioritized high-burden counties for intensified paediatric interventions, a critical evidence gap remains in developing integrated analytic frameworks that can objectively predict and validate paedi... read more
Background. Studies applying machine learning to obsessive-compulsive disorder (OCD) typically report accuracy in homogeneous samples but rarely assess model reliability, generalizability, and interpretability needed for clinical use. Methods. We app... read more
Chronic psychological stress contributes to allostatic load and is associated with cardiovascular, metabolic, and mental health disorders. Wearable devices enable continuous, noninvasive monitoring of autonomic signals such as heart rate variability ... read more
Objective To develop and evaluate a novel machine learning (ML) framework tailored to a clinical diabetes dataset and to assess whether demographic stratification enhances model performance and interpretability for multiclass diabetes classification.... read more
Mass spectrometry is used to identify chemicals to which humans are exposed, but it cannot directly determine molecular structures. Instead, structures are inferred by matching experimental spectra to libraries of spectra constructed from analyses of... read more
Global climate change has increased the frequency and severity of stressful temperatures that freshwater fishes experience, necessitating rapid and sensitive methods to monitor wild populations. Tissues used to measure transcriptional responses tradi... read more
Thyroid cancer is a heterogeneous malignancy with variable outcomes, highlighting the need for reliable biomarkers and effective risk stratification. In this study, we implemented a multi-step integrative framework to identify distinct prognostic bio... read more
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