Real-time assessment of human pluripotent stem cell (hPSC) quality is critical for reproducibility and safety in regenerative medicine, yet current methods are invasive, labor-intensive, or highly operator-dependent. We present DeepHOPE (Deep-learnin... read more
DNase1L3 is an endonuclease that fragments DNA during apoptosis and digests DNA from microparticles in plasma, shaping key features of cell-free DNA (cfDNA) and maintaining extracellular DNA homeostasis, a process implicated in autoimmunity. The comm... read more
De novo protein design has advanced rapidly in recent years, yet the programmable recognition of specific DNA sequences remains a longstanding challenge. Here we describe a deep learning based approach for designing sequence selective DNA binding pro... read more
Nanobodies exhibit antigen binding a[ffi]nities of the same order as those of antibodies, which, along with their small size and unique structural characteristics, makes them well-suited for therapeutic and diagnostic applications. The lack of coevol... read more
OBJECTIVE: Given China's rapid population ageing and substantial stroke burden, understanding the epidemiology of vascular cognitive impairment (VCI) is critical. This study aimed to systematically evaluate VCI prevalence and incidence in China from ... read more
OBJECTIVE: The primary objective of this study is to enhance the detection and staging of pressure injuries using machine learning capabilities for precise image analysis. This study explores the application of the You Only Look Once version 8 (YOLOv... read more
Accurate and efficient estimates of fine particulate matter (PM2.5) concentrations and associated exposure from smartphone photographs can provide the public with personalized risk information, helping to raise environmental risk awareness and reduce... read more
As dental caries appear as subtle, low-contrast lesions in intraoral imaging, existing deep learning models face significant challenges in the early detection of caries. While recent Transformer-based detectors have shown promising results in natural... read more
Disease progression varies with age and is influenced by underlying genetic, biochemical, and hormonal etiologies, suggesting the need for tailored monitoring, care, and medication beyond standard clinical guidelines. Specifically, in autoimmune dise... read more
The discovery of novel materials is critical for global energy and quantum technology transitions. While deep learning has fundamentally reshaped this landscape, existing predictive or generative models typically operate in isolation, lacking the aut... read more
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