Objective.Low-dose computed tomography (LDCT) reduces radiation exposure but introduces noise and artifacts that degrade diagnostic quality. Existing deep learning-based denoising methods still face challenges such as over-smoothing, loss of fine str... read more
Introduction Secondary use of electronic health records (EHRs) often requires transforming raw clinical information into research-grade data. A central step in this process is EHR phenotyping - the identification of patient cohorts defined by specifi... read more
Background Electronic health record (EHR) phenotyping underpins observational research, cohort discovery, and clinical trial screening. Large language models (LLMs) offer new capabilities for extracting phenotypes from unstructured text, but their pe... read more
Chronological age is a potent determinant of clinical events, but it is conventionally treated as a linear function of time rather than a dynamic process shaped by genetics and tissue-specific senescence. Deep learning models derived from cardiovascu... read more
Machine learning models have seen a lot of success in medical image segmentation domain. However, one of the challenges that they face are confounders or shortcuts: spurious correlations or biases in the training data that affect the resulting models... read more
Backgound: Accurate assessment of diastolic function and left ventricular (LV) filling pressure is central to heart failure diagnosis and risk stratification. Contemporary guideline algorithms rely on complex parameters that are not consistently avai... read more
Objectives: Large language models (LLMs) have shown promise in creating clinical codelists for research purposes, a time-consuming task requiring expert domain knowledge. Here, we evaluate the performance and assess failure modes of a retrieval augme... read more
Temporal resolution of physiological monitoring in intensive care varies widely across healthcare systems. Artificial intelligence models assume a uniform and fixed frequency of sampling, thus limiting the generalizability of models, especially to re... read more
Metabolic dysfunction is increasingly recognized as a risk factor for poor outcomes in breast cancer, but whether incretin-based therapies confer survival benefit beyond weight loss remains unresolved. Using a federated electronic health record platf... read more
Objective: To demonstrate the proof of principle that machine learning (ML) can be used to quantify Gleason Pattern (GP) 4 on digitized biopsy slides using multiple measurement approaches, allowing direct comparison of their prognostic performance. M... read more
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