Significance: Diffuse in vivo flow cytometry (DiFC) is an emerging technique for enumerating rare, fluorescently-labeled circulating tumor cells (CTCs) in small animals without drawing blood samples. DiFC uses detection of transient fluorescent peaks... read more
Large language model (LLM) agents have automated tool use in chemistry, but orchestrating multi step computational biology workflows spanning structure prediction, protein design, and covalent conjugation remains manually intensive. Here we present O... read more
Extracellular vesicles are increasingly recognized as important carriers of disease-associated molecular information, yet robust methods for their isolation and molecular characterization from limited clinical samples remain challenging. Here, we pre... read more
Entrenchment - epistasis that locks in amino acid differences between homologous proteins, so each disfavors substitutions toward the other's state - has been demonstrated along individual protein lineages over deep evolutionary time. Antibodies offe... read more
Electrophysiological data, which serve as a biological signal that bridges neural activity and behavioral tasks, provide an innovative approach to neuroscience research. In this study, we constructed a dataset that contains over 2000 neurons across 1... read more
We introduce GeneBench, a benchmark for AI agents on realistic multi-stage scientific data analysis in genetics and quantitative biology. Existing biology benchmarks mostly measure knowledge retrieval, execution of routine pipelines, or a single anal... read more
Computational predictions are essential to characterize the RNA-protein interaction landscape, yet a persistent gap between benchmark performance and practical utility suggests that current models have limited generalization capabilities. To address ... read more
The insular cortex (IC) integrates diverse sensory and interoceptive signals to support emotional and cognitive functions, exhibiting topologically functional distinctions. Although long-range pathways of the IC have been extensively mapped, the cont... read more
High level of protein expression is usually welcomed in industry and research, and codon optimization is widely used to achieve high expression. Methods of implementing codon optimization can be divided into two branches, one is classical methods whi... read more
MedSafe-Dx (v0), introduces a new safety-focused benchmark for evaluating large language models in clinical diagnostic decision support using a filtered subset of the DDx Plus dataset (N=250). MedSafe-Dx evaluates three dimensions: escalation sensiti... read more
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