BACKGROUND: Once considered a disease observed in older adults, type 2 diabetes is now increasingly seen in youth and adolescence. Young-onset (<40 years of age) type 2 diabetes progresses more rapidly than late-onset disease, but remains frequently ... read more
RATIONALE AND OBJECTIVES: Breast cancer is the most common malignancy among females globally and across most Asian countries. In 2022, Asia's age-standardized incidence rate (ASIR) was 34.3/100,000, with age-standardized mortality rate (ASMR) of 10.5... read more
In patients with cardiovascular disease (CVD), frailty is a significant problem due to its association with morbidity and mortality, procedural risk, and reduced tolerance to the pharmacological treatment of CVD. However, frailty is a conceptual enti... read more
Integrating genotype (e.g., transcriptomics), phenotype (e.g., imaging), and tumor microenvironment (e.g., metabolomics) is crucial to elucidating the molecular basis of ovarian cancer. However, there is a lack of robust multimodal integration method... read more
Many important phenomena in biochemistry and biology exploit dynamical features such as multi-stability, oscillations, and chaos. The construction of novel chemical systems with such rich dynamics is a challenging problem central to the fields of syn... read more
RNA-binding proteins (RBPs) orchestrate post-transcriptional processes, including splicing, cleavage and polyadenylation, and translation. Our updated RBP resource integrates data from 92 additional RBPs (286 in total) profiled by enhanced CLIP (eCLI... read more
Along busy walking paths many pedestrians walk in a group, thus challenging the collision avoidance behaviours of both the group and individual pedestrians. Here we sought to determine what factors contribute to these behaviours in a real-world envir... read more
OBJECTIVE: Predicting early symptom severity and treatment response in schizophrenia is crucial for selecting optimal therapeutic strategies. This study aimed to develop machine learning (ML) models utilizing functional near-infrared spectroscopy (fN... read more
Urinary proteomics has swiftly emerged as a formidable tool for the identification of non-invasive biomarkers and the surveillance of diseases. The progression in high-resolution mass spectrometry and data-independent acquisition techniques has facil... read more
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