AI Medical Compendium

A comprehensive toolkit for analyzing cell-free DNA genomic sequencing data in liquid biopsy.

iScience Apr 21, 2026

Liquid biopsy via plasma cell-free DNA (cfDNA) is transforming precision medicine by enabling non-invasive insights into the genomic and epigenomic landscapes of disease, especially cancer. However, the increasing diversity of cfDNA-derived features ... read more

Comment on "predictors of short-term, relapse-independent progression in multiple sclerosis: A machine learning approach based on clinical data and conventional MRI-derived features".

Journal of the neurological sciences Apr 21, 2026

A novel qVGG-4 model for optimizing a parameterized quantum circuit in a quantum-IoT-based brain tumor detection and monitoring system.

Computer methods and programs in biomedicine Apr 21, 2026

BACKGROUND: Since brain tumors (BTs) require early detection for timely and effective treatment planning, this study presents two quantum deep learning (Q-DL) approaches: a quantum Convolutional Neural Network (CNN) and a quantum Vision Transformer (... read more

Crosstalk between immune and programmed cell death and their application in colorectal cancer risk stratification.

Molecular and clinical oncology Apr 21, 2026

Programmed cell death (PCD) and cellular immunity play pivotal roles in colorectal cancer (CRC) progression; understanding their crosstalk and identifying key genes could improve risk stratification and therapy. A univariate Cox analysis was performe... read more

Systems pharmacology approaches to modeling immune training and tolerance.

Current opinion in pharmacology Apr 21, 2026

Trained immunity is defined as the epigenetic and metabolic reprogramming of innate immune cells, conferring enhanced or diminished responsiveness to secondary challenges following initial stimulation. Immune tolerance represents the state of immunol... read more

Deep Learning and Experimental Validation of BRCA1-Associated Protein-1 Missense Variant Pathogenicity in Uveal Melanoma.

Ophthalmology science Apr 21, 2026

OBJECTIVE: To benchmark the pathogenicity predictions of AlphaMissense, a deep learning model, against high-throughput functional scores from saturation genome editing (SGE) for all experimentally tested BRCA1-associated protein-1 (BAP1) missense var... read more

On-device artificial intelligence agent based on language models for electrochemical water desalination.

Water research Apr 21, 2026

Electrochemical water treatment is essential for tackling global water scarcity but remains difficult to optimize due to limited expertise and computing resources at many treatment facilities. Here, we introduce an intelligent on-device platform that... read more

Divergent macrophage-regulated T cell states determine response to Bacillus Calmette-Guérin vaccine in high-risk bladder cancer.

The Journal of clinical investigation Apr 21, 2026

BACKGROUNDPrimary therapy for high-risk bladder cancer (BCa) is repeated instillations of the tuberculosis vaccine Bacillus Calmette-Guérin (BCG). Although BCG reduces the risk of recurrence by more than half, the mechanisms underlying its immune-act... read more

Centralized pooling and federated learning for Canadian patient-level data sharing in multicenter medical AI: A scoping review.

Artificial intelligence in medicine Apr 21, 2026

Algorithms that support screening, triage, and treatment decisions depend on training data drawn from patient populations. Limited access to patient-level records across institutions and jurisdictions can reduce representation and contribute to uneve... read more

Nanomaterials reshaping cancer radiotherapy: Radiosensitization mechanisms, delivery and theranostic platforms, multimodal synergy, and clinical translation strategies.

Materials today. Bio Apr 21, 2026

Radiotherapy (RT) remains a cornerstone of cancer management but is fundamentally constrained by normal tissue toxicity, intrinsic and acquired radioresistance, and hypoxia- and microenvironment-driven dose-response plateaus. Engineered nanomaterials... read more

Artificial Intelligence Medical Compendium