PURPOSE: Metachromatic leukodystrophy (MLD) is a rare lysosomal storage disorder characterized by progressive white matter demyelination. Quantification of demyelinated white matter on MRI-typically expressed as the demyelination load-serves as a key... read more
AIMS/HYPOTHESIS: Clinically actionable biomarkers that accurately reflect the health status of the beta cell are needed to improve risk stratification and optimise the timing of interventions in type 1 diabetes. We hypothesised that inflammatory stre... read more
ALOX15 is a key regulatory enzyme in multiple pathological processes including inflammation, cancer, and cardiovascular disease, rendering the development of potent inhibitors of this enzyme of significant clinical importance. This study aims to scre... read more
OBJECTIVE: This study aimed to develop and validate a deep learning prediction model using longitudinal multimodal ultrasound imaging for early identification of treatment-sensitive and treatment-resistant carotid plaques in patients receiving lipid-... read more
Cancer remains one of the leading causes of death worldwide and continues to pose a serious public health challenge. The limited success of many current treatments-often due to toxicity, poor selectivity, and the development of drug resistance-highli... read more
BACKGROUND: Obesity-induced left ventricular diastolic dysfunction (LVDD), associated with ectopic fat and dysfunctional epicardial adipose tissue (EAT), is emerging as a key research area due to its increasing prevalence and links to metabolic-assoc... read more
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