BACKGROUND: Multimorbidity, living with 2 or more long-term health conditions, is increasing globally and now affects over one-quarter of adults in England. People with multiple long-term conditions (MLTC) face complex health and treatment challenges... read more
BACKGROUND: Despite the growing emphasis on open science and equity in research, qualitative data capturing diverse human experiences and perspectives are rarely reused beyond the original study. Increasingly, data repositories are used to make these... read more
BACKGROUND: Clinical decision support (CDS) tools that provide patient-specific and evidence-based information to clinicians and care managers regarding patient risk for adverse outcomes have been a part of health care for decades. However, modern CD... read more
BACKGROUND: Plantar pressure imaging is a stable modality that reflects gait-related biomechanical characteristics and has been used increasingly for gait assessment and recognition. However, plantar pressure images are high dimensional and nonlinear... read more
The rapid integration of large language models into electronic medical record systems introduces a critical theoretical vulnerability. Drawing on foundational computer science proofs of "model collapse," this viewpoint introduces the concept of "Clin... read more
BACKGROUND: The American Society of Anesthesiologists Physical Status (ASA-PS) classification is integral to preoperative risk assessment; yet, assignment remains subjective and labor-intensive. Recent large language models (LLMs) process free-text e... read more
Annual review of biomedical data science
Apr 21, 2026
Protein-protein interactions (PPIs) form highly dynamic and context-specific networks that vary across cell types and perturbation states. Mapping and understanding these context-dependent interactomes is essential for unraveling cellular organizatio... read more
PURPOSE: To develop and evaluate a machine learning (ML)-based model for predicting keratoconus (KCN) progression in an Iranian cohort. METHODS: This retrospective study included 1,000 eyes of 529 patients with KCN (mean age: 31.1±8.0 years; 63.3% ma... read more
The American journal of tropical medicine and hygiene
Apr 21, 2026
Leptospirosis is difficult to diagnose because of protean nonspecific clinical manifestations and the lack of rapid, actionable laboratory testing. A previously healthy woman who presented with nausea is described in the present study. She had modest... read more
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