AI Medical Compendium

Rhythms of mood: Bidirectional regulation of molecular clocks and neurotransmission in affective disorders.

Neuroscience and biobehavioral reviews Apr 20, 2026

Mood disorders, primarily major depressive and bipolar disorder, are characterized by significant neurochemical dysregulation and disturbances in biological rhythms. Recent evidence suggests for a complex, bidirectional interplay between the molecula... read more

Serum-antibody Profiling of H3N2-infected Ferrets Using a Combinatorial Phage-display Random Peptide Library.

Journal of molecular biology Apr 20, 2026

The repertoire of antibodies in serum, known as the "IgOme", is highly diverse and unique to each individual as it reflects the cumulative history of personal encounters with pathogens. Consequently, profiling this repertoire may serve as a diagnosti... read more

Diagnosis of Leukemia from Bone Marrow Flow Cytometry Data Using Deep Learning and Explainable Artificial Intelligence.

The American journal of pathology Apr 20, 2026

Leukemia is a life-threatening blood cancer requiring rapid and accurate diagnosis to improve patient survival. Although flow cytometry offers powerful multiparametric analysis, manual interpretation remains slow, subjective, and, thus, prone to erro... read more

Next-Generation Disease Profiling by Integrating Histopathology with Spatial Multi-Omics Data.

The American journal of pathology Apr 20, 2026

The field of pathology has experienced several transformative changes in recent years with the advent of digital pathology and spatial multi-omics. These technologies have enhanced every aspect of pathology practice, from streamlining daily workflows... read more

Amino acid metabolism in retinal diseases: Mechanisms, diagnostics, and therapeutic opportunities.

Experimental eye research Apr 20, 2026

Amino acid metabolism serves as a central hub linking retinal energy supply, neurotransmission, and cell signaling, which is critical for maintaining retinal structure and function. This review summarizes the molecular mechanisms by which abnormal am... read more

The effect of robot-based interventions on depression in older adults with cognitive impairment: A systematic review and meta-analysis.

Archives of gerontology and geriatrics Apr 20, 2026

OBJECTIVE: To assess the effectiveness of robot-based interventions in improving depressive symptoms among older adults with cognitive impairment, and to examine secondary effects on anxiety symptoms and cognitive function. DESIGN: A systematic revie... read more

Development and validation of an ensemble machine learning model to predict survival in locally advanced rectal cancer: A multicenter, retrospective study.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology Apr 20, 2026

BACKGROUND: Patients identified with locally advanced rectal cancer (LARC) demonstrate a varied prognosis after undergoing neoadjuvant chemoradiotherapy (nCRT), highlighting the essential need for precise predictions of outcomes. PURPOSE: The aim of ... read more

From prediction to practice: early implementation of a machine learning-based hospitalization prediction tool in the emergency department.

International journal of medical informatics Apr 20, 2026

BACKGROUND: Machine learning (ML) models can accurately predict hospital admissions in emergency departments (EDs), but real-world adoption remains rare. We evaluated the feasibility and early implementation of an ML-based hospitalization prediction ... read more

Oil spill detection on sea surface with dual-polarimetric SAR imagery integrating polarization features and oil-seawater boundary information.

Journal of hazardous materials Apr 20, 2026

Oil Spill can cause a series of ecological disasters and irreversible damages to marine environment, making the timely detection of oil films on the sea surface critical. In this field, Polarimetric Synthetic Aperture Radar (PolSAR) is an effective t... read more

Making waves: Wastewater sludge holds untapped antimicrobial potential.

Water research Apr 20, 2026

Wastewater treatment plants are widely recognized as critical nodes in the environmental dissemination and control of antimicrobial resistance (AMR). This risk-focused view is warranted, but incomplete. Wastewater sludge is one of the largest enginee... read more

Artificial Intelligence Medical Compendium