AI Medical Compendium

Deep learning inference of cell type-specific gene expression from breast tumor histopathology.

NPJ precision oncology Apr 16, 2026

Cell type-specific gene expression from single-cell RNA sequencing (RNA-seq) is valuable for breast cancer precision oncology but available cohorts are still limited due to its high cost. Deconvolution methods infer cell type-specific expression from... read more

Divergent synthesis of γ-lactones and cyclopropanes via efficient [1 + 4] and [1 + 2] annulations of amide-sulfoxonium ylides.

Communications chemistry Apr 16, 2026

Functionalized γ-lactones and cyclopropanes, especially those bearing amide substituents, play important roles in diverse chemical and pharmacological processes, but their synthesis remains challenging. Here, we report a high-throughput protocol that... read more

Harnessing Surface Instabilities for Functional Materials: Mechanics, Morphology, and Emerging Applications.

Nano-micro letters Apr 16, 2026

Surface instabilities, such as wrinkling, folding, and creasing, have transcended their traditional perception as mechanical failures to emerge as a powerful and versatile paradigm for engineering functional surface morphologies in soft materials. Th... read more

Screening for peripheral blood biomarkers and construction of a diagnostic model for adolescent depression based on metabolomics and machine learning.

BMC psychiatry Apr 16, 2026

Performance of large language models in endodontics: accuracy, consistency, and benchmarking with consensus guidelines.

BMC oral health Apr 16, 2026

Role of artificial intelligence in head and neck surgery - A narrative review.

Turkish journal of surgery Apr 16, 2026

The advent of artificial intelligence (AI) in the field of head and neck surgery has remarkably impacted in various domains, including investigation, diagnosis, pre-operative decision making, surgical planning, rehabilitation, and so on. Head and nec... read more

Reduction of Acquisition Time in FTIR Spectroscopy via Spectral Super-Resolution by Deep Learning.

Analytical chemistry Apr 16, 2026

This study aims to enhance spectral resolution in Fourier transform infrared spectroscopy (FTIR), a crucial element for in-depth molecular analysis in clinical diagnosis. We address this challenge by developing spectral super-resolution models based ... read more

Nanotrap-AI Integration Enables Ultra-Sensitive Point-of-Care HIV Testing.

ACS nano Apr 16, 2026

Early HIV detection using noninvasive samples remains challenging because oral fluid contains extremely low antibody levels and enzymatic inhibitors that limit the sensitivity of lateral-flow assays (LFAs). We introduce BE-SMART-HIV, a diagnostic pla... read more

A Reinforcement Learning-Guided Genetic Algorithm Integrating Medicinal Chemistry-Inspired Molecular Transformations.

Journal of chemical information and modeling Apr 16, 2026

Achieving optimal target activity while maintaining synthetic accessibility and drug-likeness represents a major challenge in computational drug discovery. Existing de novo generative models often yield chemically invalid or synthetically intractable... read more

Scenario-based evaluation of large language models for reference accuracy in dermatology: literature retrieval on latent tuberculosis in psoriasis patients on anti-IL-17/23 therapy.

Cutaneous and ocular toxicology Apr 16, 2026

BACKGROUND: Large language models (LLMs) could accelerate clinical literature searches, but their reliability is compromised by "hallucinations" generating false references. This study compared three general-purpose LLMs using a standardized dermatol... read more

Artificial Intelligence Medical Compendium