ObjectivesTo develop and evaluate predictive models for unused outpatient appointments (missed or cancelled) using a large national electronic health record (EHR) repository in the United States.
DesignRetrospective observational study using machine... read more
Drug-resistant tuberculosis (TB), characterized by prolonged treatment regimens and suboptimal treatment outcomes, remains a major obstacle to global TB elimination. Advances in sequencing technologies have enabled the development of machine-learning... read more
ABSTRACT Background: RNA editing is a post-transcriptional modification that alters the sequence of an RNA transcript. Two types of RNA editing were found in mammals, involving the enzymatic deamination of either adenosine to inosine (A-to-I) or cyti... read more
Peripheral Blood transcriptome analysis evaluated the bulk transcript abundance (TA) covering all leukocyte cell populations. However, there are 2 main problems in using bulk expression as biomarkers: (1) A long list of differential expression genes ... read more
Spatiotemporal control over cell fate and behaviour within bioprinted constructs remains a key challenge in tissue engineering. Optogenetics offers versatile potential for non-invasive regulation of biological processes. Yet, its integration within l... read more
Category-selective areas in the occipitotemporal cortex (OTC) are typically characterized by broad tuning, yet neuroimaging suggests a finer-grained organization reflecting distinct computational roles. We combined image-level fMRI with artificial ne... read more
Quantitative genetic approaches such as genome-wide association studies and genomic prediction are widely used to identify favourable genetic variation, but they have limited resolution due to linkage disequilibrium. Comparative genomics approaches, ... read more
Background Individual clinical cognitive assessments (CCA) for Alzheimer's disease (AD) provide broad disease stratification but are limited in sensitivity and specificity, requiring integration of multiple CCA for optimal disease staging. Recent wor... read more
BACKGROUND: Social media influencers who promote e-cigarettes on Instagram or TikTok for tobacco brands use marketing tactics to increase the appeal of their promotional content, for example, depicting e-cigarettes alongside healthy lifestyle or ente... read more
The rapid advancement of diffusion-based generative models has made face forgery detection a critical challenge in digital forensics. Current detection methods face two fundamental limitations: poor cross-domain generalization when encountering unsee... read more
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