AI Medical Compendium

Surgically Relevant Knee Phenotypes: The Modified Coronal Plane Alignment of the Knee (mCPAK) System - A Deep Learning-based Classification.

The Journal of arthroplasty Apr 10, 2026

BACKGROUND: The coronal plane alignment of the knee (CPAK) classification proposes nine knee phenotypes based on constitutional limb alignment and joint line obliquity (JLO). However, there is considerable confusion and variability in defining types,... read more

Oral Health and Social Engagement of Older Adults: A Longitudinal Study.

Journal of dentistry Apr 10, 2026

OBJECTIVES: This study examines whether better oral health is associated with greater social engagement in later life and whether oral health and social engagement are associated with depressive symptoms among older adults. METHODS: We analyze Waves ... read more

Print, check, repeat: digital quality by design for 3D-printed medicines using OpenAI models.

International journal of pharmaceutics Apr 10, 2026

Semi-solid extrusion three-dimensional printing (SSE-3DP) technology has emerged as a versatile manufacturing approach across a wide array of industries. Despite the rapid progress of additive manufacturing technologies and their increasing translati... read more

GalaxyCDock: Webserver for Covalent Protein-Ligand Binding Mode Prediction.

Journal of molecular biology Apr 10, 2026

Covalent ligands represent small molecules including a reactive moiety that forms a covalent bond, enabling the targeting of proteins that are otherwise difficult to modulate. Accurate binding prediction is critical for achieving target specificity a... read more

Deep learning on genome-wide association studies to predict the patient-specific risk of radiation-induced erectile dysfunction.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology Apr 10, 2026

OBJECTIVE: Radiation-induced erectile dysfunction (RIED) is a frequent, unpredictable complication following radiotherapy for prostate cancer. We hypothesized that genome wide genetic variants and clinical data could be analyzed using a novel deep le... read more

Scoparone alleviates cisplatin-induced acute kidney injury by inhibiting 5-lipoxygenase-mediated ferroptosis.

Toxicology and applied pharmacology Apr 10, 2026

Ferroptosis, a regulated form of cell death, plays a critical role in renal tubular epithelial cells during acute kidney injury (AKI). Scoparone, a bioactive coumarin, confers organ protection in cardiovascular, hepatic, and inflammatory disorders. H... read more

Genomic Determinants of Response to Alpelisib Plus Fulvestrant in the SOLAR-1 Trial.

Annals of oncology : official journal of the European Society for Medical Oncology Apr 10, 2026

BACKGROUND: Approximately 40% of patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-), advanced breast cancer (ABC) have PIK3CA alterations, which contributes to endocrine therapy resistance. Alpeli... read more

A hybrid framework for effective microscopic cell counting segmentation integrating Light-U-net with watershed.

Experimental eye research Apr 10, 2026

Glaucoma is a major cause of irreversible blindness worldwide, resulting in the progressive degeneration of retinal ganglion cellss (RGCs), which makes early disease detection critical for effective management.Traditional methods for monitoring RGCs ... read more

Predicting 10-2 SITA Standard from 24-2C SITA Faster: Development and Validation of Deep24-2C.

Ophthalmology. Glaucoma Apr 10, 2026

PURPOSE: To develop and validate Deep24-2C, a machine learning (ML) model that reconstructs comprehensive Humphrey Field Analyzer (HFA) 10-2 visual field (VF) thresholds from HFA 24-2C. DESIGN: Retrospective study. PARTICIPANTS: A total of 3,653 HFA ... read more

Neuroplasticity after Stroke: Adaptive and Maladaptive Mechanisms in Evidence-Based Rehabilitation.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association Apr 10, 2026

BACKGROUND AND PURPOSE: Ischemic stroke remains a leading cause of long-term disability and persistent motor deficits. While neuroplasticity drives post-stroke recovery, clinical rehabilitation does not always effectively utilize this mechanism. Impo... read more

Artificial Intelligence Medical Compendium