The non-invasive diagnosis and risk stratification of prostate cancer (PCa) remain clinically challenging due to the limited specificity of prostate-specific antigen (PSA). In this retrospective study, we applied a comparative machine learning (ML) f... read more
While thousands of AI prediction models are published annually, few are adopted into routine practice, partly because improved statistical performance does not necessarily translate into meaningful impact on clinical decision-making. We conducted a p... read more
Similar to proteins, many RNAs fold into three-dimensional (3D) structures to perform biological functions. Here we present the trRosettaRNA server, a web-based platform for automated RNA 3D structure prediction using deep learning. The primary input... read more
Large Language Models (LLMs) are increasingly deployed in medicine. However, their utility for non-generative clinical prediction is under-evaluated, and they are often assumed to be inferior to specialized models, creating potential for misuse and m... read more
The assessment of coronal balance is critical for cosmetic appearance and quality of life in patients with adolescent idiopathic scoliosis (AIS), yet its manual quantification remains constrained by substantial workflow demands and inherent subjectiv... read more
BACKGROUND: Accurate estimation of the retinal age, defined as the age predicted from fundus photographs by a deep-learning model trained on chronological age, provides a non-invasive biomarker of biological ageing and disease risk. METHODS: In this ... read more
Cancer remains a leading cause of human mortality worldwide, imposing a substantial public health burden. A deep understanding of the tumor microenvironment (TME) is essential for improving cancer care. Erythroid progenitor cells (EPCs) were traditio... read more
INTRODUCTION: Preoperative 2D digital templating aids surgical planning in total hip arthroplasty (THA). We evaluated template accuracy by comparing preoperative templated measurements with postoperative findings and final implant sizes. METHODS: We ... read more
The prescription is a critical bridge between medical diagnosis and therapeutic intervention, embodying a complex decision that balances medical evidence, clinical experience, and individual patient needs. However, the prescribing process faces signi... read more
Invasive venous blood draws remain the clinical standard for hematology, yet they are invasive, time-consuming, and costly. We introduce Video-to-Vessels, a computer-vision pipeline that converts high-magnification videos of bulbar conjunctiva capill... read more
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