Here, we present Lancet2, an open-source somatic variant caller designed to improve detection of small variants in short-read sequencing data. Lancet2 introduces significant enhancements, including: (i) Improved variant discovery and genotyping throu... read more
Current problems in diagnostic radiology
Apr 7, 2026
Academic radiology departments in the United States are essential to patient care, education, research, and innovation, yet they face growing challenges such as staffing shortages, rising clinical demands, limited protected academic time, and difficu... read more
Parkinson's disease (PD) is a complex, progressive neurodegenerative disorder characterized by high heterogeneity and diagnostic challenges in its early stages. This study aimed to develop and validate a multimodal machine learning model for early PD... read more
The scarcity of high-quality Cone Beam Computed Tomography (CBCT) datasets with Three-Dimensional (3D) annotations hinders advancements in automated dental implant planning. Existing datasets lack precise 3D localization of tooth loss sites, particul... read more
Simulations of optical spectra can provide key insights to aid experimental interpretation of electronic excitation phenomena. For chromophores in the condensed phase, these spectra, which incorporate the coupling between electronic excitation and mo... read more
The flow of vibrational energy in proteins is mediated both by protein structure and structural fluctuations. However, detailed information about contributions of physical properties that mediate energy flow is still lacking. In this report, we prese... read more
3D Light Detection and Ranging (LiDAR) has gained increasing attention in the field of human motion analysis due to its capability to non-invasively capture dynamic 3D pose data. However, accurate extraction of motion information from sparse and unor... read more
ESMO real world data and digital oncology
Apr 7, 2026
BACKGROUND: Clinical trial enrollment in oncology remains critically low, with fewer than 5% of eligible adults participating, in large part due to the complexity and labor intensity of eligibility screening. We prospectively evaluated a neuro-symbol... read more
ESMO real world data and digital oncology
Apr 7, 2026
BACKGROUND: Unstructured oncology consultation notes contain rich clinical information that may support survival prediction. Open-weight large language models (LLMs) can utilize these notes with zero-shot inference or fine-tuning, but their relative ... read more
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