Cardiovascular disease (CVD) is a major comorbidity in asthma and chronic obstructive pulmonary disease (COPD), yet the contribution of artificial intelligence (AI) and machine learning (ML) to CVD risk assessment and management in these conditions r... read more
OBJECTIVES: This study aimed to validate an automated method for detecting tooth loss in intraoral scans (IOS) compared to clinical evaluations in a population-based sample. METHODS: 897 IOSs from 453 participants of the 1982 Pelotas Birth Cohort wer... read more
OBJECTIVES: To benchmark late-2025 general-purpose multimodal large language models (LLMs) on the Japanese National Dental Examination (JNDE) and to reassess a previously identified persistent-failure set. METHODS: GPT-5.2T, Claude 4.5, and Gemini 3 ... read more
Major depressive disorder (MDD) is a heterogeneous condition with varied responses to pharmacological, psychotherapeutic, and neuromodulation interventions. Identifying neuroimaging biomarkers predictive of treatment response could facilitate persona... read more
Naunyn-Schmiedeberg's archives of pharmacology
Apr 5, 2026
Lung adenocarcinoma (LUAD) is one of the leading causes of cancer-related deaths worldwide, and its complex tumor microenvironment (TME) is a key barrier to treatment. PANoptosis is a novel programmed cell death mechanism that integrates features of ... read more
Naunyn-Schmiedeberg's archives of pharmacology
Apr 5, 2026
Cutaneous squamous cell carcinoma (cSCC) involves complex immune interactions. This study aimed to identify a T cell-related gene signature to characterize the immune landscape and aid in molecular diagnosis. We integrated single-cell RNA sequencing ... read more
The visual detection of early enamel caries in intraoral photographs is challenging due to subtle lesion appearance and diagnostic subjectivity. This study aimed to develop and validate an explainable, quantum-simulated deep learning framework for th... read more
The complementarity-determining regions (CDRs) of antibodies are loop structures that are key to their interactions with antigens and are of high importance to the design of novel biologics. Existing approaches for characterizing the diversity of CDR... read more
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