This article provides a comprehensive overview and comparative analysis of China's forthcoming drug data exclusivity system, contextualizing it within global frameworks. It presents the current data exclusivity regimes of the United States, Canada, t... read more
BACKGROUND: Bipolar disorder (BD) is a chronic mental illness with recurrent mood episodes, with up to 70% of patients relapsing within two years. Early detection of prodromal symptoms is critical for timely intervention but remains challenging. Wear... read more
Aedes aegypti, the primary vector of dengue, yellow fever, Zika, and chikungunya, poses serious public health threats, especially in tropical regions. With limited vaccine availability, innovative control strategies like the Sterile Insect Technique ... read more
Polyethylene terephthalate (PET) hydrolases efficiently hydrolyze the ester bonds in PET, converting it into valuable monomers or oligomers, offering a sustainable biological solution to global PET plastic pollution. However, the large-scale developm... read more
Udder conformation is a crucial phenotype in dairy cows as it relates to their health and productivity, particularly in Automated Milking Systems (AMS). As such, this project aims to (1) develop an automated pipeline that extracts udder phenotypes fr... read more
Bovine colostrum (BC) is essential for neonatal survival and human health, owing to its rich bioactive content. However, highly abundant proteins constrain the proteome depth of BC. By integrating magnetic nanoparticle enrichment of low-abundance pro... read more
Staphylococcus aureus is a leading cause of intramammary infections (IMI) in Canadian dairy herds and is frequently isolated from both clinical and subclinical mastitis cases. Persistent IMI caused by S. aureus are of particular concern, as they are ... read more
Bioactive peptides derived from dairy proteins are increasingly recognized for their dual capacity to enhance sensory attributes and provide health-promoting functions. In fermented dairy products such as yogurt, proteolysis releases a diverse array ... read more
PROBLEM: Health systems are rapidly integrating generative artificial intelligence (GenAI) into clinical workflows, introducing safety risks including hallucinations and automation bias. These risks threaten patient safety when frontline nurses lack ... read more
European journal of medicinal chemistry
Apr 3, 2026
Predicting Drug-Target Affinity (DTA) with high fidelity is critical for accelerating hit-to-lead optimization and understanding mechanism of action. While deep learning has transformed this field, current approaches often struggle with the effective... read more
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