Supervised deep learning-based image analysis models using whole slide images (WSIs) have been reported to be effective for detecting simple histopathological findings in laboratory animals. However, there are no models that simultaneously detect mul... read more
Over the past decade, the burden of mental disorders has grown while services remain capacity-constrained, pushing generative artificial intelligence toward psychiatric practice. This narrative review outlines how large language and multimodal models... read more
The visual detection of early enamel caries in intraoral photographs is challenging due to subtle lesion appearance and diagnostic subjectivity. This study aimed to develop and validate an explainable, quantum-simulated deep learning framework for th... read more
Naunyn-Schmiedeberg's archives of pharmacology
Apr 5, 2026
Cutaneous squamous cell carcinoma (cSCC) involves complex immune interactions. This study aimed to identify a T cell-related gene signature to characterize the immune landscape and aid in molecular diagnosis. We integrated single-cell RNA sequencing ... read more
Naunyn-Schmiedeberg's archives of pharmacology
Apr 5, 2026
Lung adenocarcinoma (LUAD) is one of the leading causes of cancer-related deaths worldwide, and its complex tumor microenvironment (TME) is a key barrier to treatment. PANoptosis is a novel programmed cell death mechanism that integrates features of ... read more
Major depressive disorder (MDD) is a heterogeneous condition with varied responses to pharmacological, psychotherapeutic, and neuromodulation interventions. Identifying neuroimaging biomarkers predictive of treatment response could facilitate persona... read more
Journal of computer-aided molecular design
Apr 4, 2026
3-Mercaptopyruvate sulfurtransferase (3-MST), a key enzyme in sulfur metabolism, has recently gained attention as a potential anticancer target. However, reported 3-MST inhibitors remain limited, motivating the exploration of new scaffolds such as na... read more
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