This paper reports on insights from the OPTIMA (Optimal Treatment for Patients with Solid Tumours in Europe Through Artificial Intelligence) prototyping workshop held in Berlin from November 6 to November 8, 2024. Through integrated analysis of clini... read more
Drug-resistant epilepsy (DRE) is a complex neurological disease that accounts for 30%-40% of all epilepsy cases. Its pathogenesis and treatment have always been research hotspots in this field. In recent years, interdisciplinary research on DRE has g... read more
Generative artificial intelligence (AI) is transforming scientific communication in health, offering opportunities to improve the quality and efficiency of academic writing. This article provides practical guidance for healthcare professionals on the... read more
UNLABELLED: Metastasis is the leading cause of cancer deaths. To develop strategies for intercepting metastatic progression, a better understanding of how tumor cells adapt to vastly different organ contexts is needed. To investigate this question, a... read more
BACKGROUND: Urinalysis is a standard clinical test that includes the microscopic examination of urinary sediment to identify formed elements. Manual evaluation by laboratory technicians is time-intensive and subject to human error. Automated analysis... read more
UNLABELLED: Pediatric sarcomas present diagnostic challenges due to their rarity and diverse subtypes, often requiring specialized pathology expertise and costly genetic tests. To overcome these barriers, we developed a computational pipeline leverag... read more
BACKGROUND: Rare diseases affect more than 300 million people globally, and only about 5% have approved therapies. Lysosomal storage disorders (LSDs) exemplify the diagnostic and long-term care complexity typical of rare diseases, and digital health ... read more
Genetic homogenization due to chronic clonal propagation poses a notable challenge to the sustainable utilization of Coptis chinensis Franch. We developed a novel elite cultivar, 'Chulian No. 1', with superior yield (+34%), disease resistance, and ph... read more
RNA biology is undergoing a transformative revolution driven by AI foundation models. These models learn the intricate relationships between RNA sequence, structure, and function by training on vast, diverse datasets spanning millions of RNA molecule... read more
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