Background: Previous recommendations on screening for prostate cancer relied on ongoing trials of screening with prostate-specific antigen (PSA), which may have lacked sufficient follow-up duration to fully examine effects on mortality and overdiagno... read more
Neonates requiring intensive care are at increased risk for long-term neuropsychiatric disorders. However, clinical adoption of risk prediction models remains limited when their performance lacks adequate interpretability for informed clinical decisi... read more
Deep learning methods, including deep representation learning (DRL) approaches such as variational autoencoders (VAEs), have been widely applied to cancer omics data to address the high dimensionality of these datasets. Despite remarkable advances, c... read more
Based on single-cell RNA sequencing data, differentially expressed genes (LMR DEGs) between colorectal cancer liver metastasis epithelium and primary colorectal cancer epithelium show potential as novel biomarkers for colorectal cancer prognosis. Thi... read more
Reconstructing natural images from brain activity represents one of the most compelling demonstrations of the synergy between modern neuroimaging and machine learning. However, the computational pipelines underlying these results remain scarcely acce... read more
Biological brain aging is a major determinant of cognitive decline and neurodegenerative disease, yet scalable and intervention-ready brain aging biomarkers remain limited. Here, we develop an electroencephalography (EEG)-based brain age clock using ... read more
Generating realistic single-cell transcriptomic profiles from structured biological descriptions would enable controlled simulation, data augmentation, and hypothesis-driven cell-state creation---yet no existing method combines text--cell alignment w... read more
The identification of suitable lead molecules in the vast chemical space is a critical and challenging task in drug discovery campaigns. Recently, it has been demonstrated that large-scale virtual screening provides a powerful approach to accelerate ... read more
Human diseases and adverse drug reactions are ultimately recognized through clinical symptoms, yet the molecular determinants of most symptoms remain unknown. To address this key issue, we present PHENOCAUZ, a computational framework that links sympt... read more
Protein language models (PLMs) are increasingly central to protein engineering and drug discovery. Many high-performing systems, however, rely on large parameter counts, multiple sequence alignments (MSAs), explicit structural inputs, or computationa... read more
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