CONTEXT: Free energy calculations have evolved from specialized theoretical tools to essential components of modern molecular design, particularly in pharmaceutical research where alchemical binding free energy methods now guide lead optimization dec... read more
PURPOSE: Sarcopenia diagnosis requires identifying low muscle mass (LMM), typically via dual-energy X-ray absorptiometry (DXA). However, DXA's limited accessibility restricts large-scale screening. This retrospective study aimed to develop and valida... read more
The mechanisms underlying the continuum from asymptomatic intracranial atherosclerotic stenosis (aICAS) to symptomatic intracranial large-artery atherosclerotic ischemic stroke (iLAA-IS) remain unclear. We investigated the gut microbiota-metabolite a... read more
NPJ primary care respiratory medicine
Mar 28, 2026
Early COPD diagnosis is vital for effective management, yet conventional tools such as professional spirometers are often inaccessible in resource-limited settings. We present Cough Search, a smartphone-based deep learning algorithm that uses volunta... read more
Risk stratification during hospitalization may support real-world discharge planning. We developed and validated machine learning models and an interpretable risk score to predict discharge destination among patients hospitalized with Parkinson's dis... read more
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