Purpose: Manual screening for trial eligibility is inefficient and costly. We prospectively evaluated a large language model (LLM)-assisted prescreening workflow across multiple active trials. Methods: We deployed a retrieval-augmented generation LLM... read more
The present study evaluates the real-world clinical predictive performance of FDA-authorized artificial intelligence (AI) devices used in radiology, focusing on the false positive paradox (FPP) and its implications for clinical practice. To do this, ... read more
Longitudinal electronic health records (EHRs) form irregular event sequences that mix multiple clinical coding systems and care settings. Learning transferable patient representations requires modeling both within-encounter code composition and long-... read more
Purpose: Suicide and self-harm are major public health concerns characterized by substantial clinical and psychosocial heterogeneity. While latent class analysis has been used to identify subgroups of people with suicidal behavior, the extent to whic... read more
Abstract Background: Insufficient physical activity, excessive sedentary time, and suboptimal sleep are linked to premature mortality and chronic disease and may contribute to social inequalities in health, but most evidence is self-reported. Device-... read more
Digital health technologies, including machine learning (ML), are transforming infectious disease management, however ML models for HIV care have been limited by data sharing restrictions that prevent multi-site collaboration. Federated Learning (FL)... read more
Background: Diagnosing the over 700 known rare bone diseases (RBDs) is inherently challenging and often requires extensive time and multiple clinical visits. Effective treatment, particularly for RBDs with approved therapies, depends on early and pre... read more
Background Narcolepsy is a rare, lifelong neurological disorder that often begins in childhood or adolescence. Diagnosis is frequently delayed because current diagnostic testing relies on specialist in-patient sleep investigations: overnight polysomn... read more
Background Chronic subdural hematoma (cSDH) recurrence requiring reoperation occurs in 5-33% of cases, representing a substantial clinical and economic burden. The ability to predict recurrence could enable risk-stratified surveillance protocols, pot... read more
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