Background: The 2017 American College of Cardiology/American Heart Association (ACC/AHA) guideline lowered diagnostic threshold for hypertension, encouraging earlier treatment initiation in the U.S. compared to UK, where the National Institute for He... read more
Background Microvascular dysfunction is a key component of many cardiovascular (CV) diseases. Assessing the retinal microvasculature through retinal imaging may therefore provide a window into evaluating a range of CV diseases. This study sought to g... read more
Background: Large language models (LLMs) perform well on standardized medical exam questions, but their reliability for complex hematology decision making is uncertain. We compared four general-purpose LLMs (GPT-4o, GPT-o3, Claude Sonnet 4, and DeepS... read more
Background: Large language models (LLMs) have been evaluated as tools to assist rare disease diagnosis, yet evidence on their accuracy remains fragmented. We conducted a systematic review and meta-analysis to synthesize the available evidence on the ... read more
Background: Artificial intelligence (AI) has rapidly garnered interest in healthcare, with research showing promise to improve quality, efficiency, and outcomes. Cancer care's multidisciplinary nature and high coordination demands are well positioned... read more
Lipoprotein composition is altered in sepsis, and supplementation with high-density lipoproteins has been reported to improve outcomes in experimental settings. In this study, we aimed to investigate the nature and inter-individual variability in the... read more
Purpose: Early recognition of deterioration in patients with suspected infection at the emergency department (ED) is important. Current clinical scoring systems show limited discriminative performance for early deterioration. Continuous electrocardio... read more
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia worldwide and is strongly associated with increased risks of stroke, heart failure, and mortality. Traditional methods to predict AF and prognostic its associated risks often fail to c... read more
Maladaptive reward learning and decision-making circuity are key factors in the onset and progression of alcohol use disorder and have therefore emerged as key targets for neuropsychological and pharmacological interventions. Probabilistic reversal l... read more
A key question in human neuroscience is to understand how individual differences in brain function relate to cognitive differences. However, the optimal condition of brain function to study between-person differences in cognition remains unclear. Whi... read more
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