AI Medical Compendium

CRISPR/Cas12a: A Comprehensive Review from Structural Foundations to Applications in Nucleic Acid Precision Detection.

Journal of agricultural and food chemistry Mar 26, 2026

CRISPR/Cas12a technology, characterized by its distinctive trans-cleavage activity, has evolved beyond its gene-editing function to emerge as a powerful tool for molecular detection. This review systematically delineates its structural foundation and... read more

Machine Learning-Enhanced Orbital-Free Density Functional Theory.

Journal of chemical theory and computation Mar 26, 2026

Orbital-free density functional theory (OF-DFT) is the ultimate large-scale ab initio method, allowing calculations with 106 atoms and beyond to be done relatively routinely with relatively modest computational resources. The key bottleneck to its wi... read more

Multicomponent Simultaneous Identification Network (MSINet): An Advanced Deep Learning Model for Boosting Multiplex SERS Detection in Untreated Real Samples.

Analytical chemistry Mar 26, 2026

Surface-enhanced Raman spectroscopy (SERS) represents unique advantages for on-site analysis due to its high sensitivity, high specificity, and applicability to gaseous, liquid, and solid samples. However, the complex and unknown components in matric... read more

Cellular and subcellular specialization enables biology-constrained deep learning.

Cell reports Mar 26, 2026

Learning depends on changes in neuronal synaptic strengths. While cellular mechanisms of plasticity have been extensively studied experimentally, our understanding of how plasticity is organized across neural populations comes largely from training a... read more

At the Edge of Chaos: Complexity Science and Critical Care in the Era of Artificial Intelligence.

Shock (Augusta, Ga.) Mar 26, 2026

Critical care unfolds at the crossroads of highly complex, nonlinear systems. The intersection of pathophysiology, human behavior, and clinical operations exemplifies this complexity. We can frame critical illnesses along two dimensions of complexity... read more

Screening for Alzheimer's disease in the community using an AI-driven screening platform: design of the PREDICTOM study.

The journal of prevention of Alzheimer's disease Mar 26, 2026

BACKGROUND: Recent developments in physiological, imaging and digital biomarkers combined with the approval of new disease-modifying drugs against Alzheimer's disease (AD) and diagnostic blood tests provide an opportunity to shift the first diagnosti... read more

K2CO3-Fe2O3 catalyzes sludge ceramsite formation: ML-elucidated nucleation-growth kinetics.

Journal of environmental management Mar 26, 2026

Urban sewage sludge generation continues to rise annually, making its resource recovery into lightweight ceramsite a prominent research focus. This study systematically performed 30 distinct thermogravimetric (TG) experimental conditions-each replica... read more

Optimized hybrid deep learning model for accurate prediction of effluent quality in wastewater treatment plants.

Journal of environmental management Mar 26, 2026

Accurate prediction of effluent quality in wastewater treatment plants (WWTPs) is critical for improving effluent compliance rates and reducing energy consumption. Current water quality prediction models are limited by inadequate data quality, subopt... read more

Artificial intelligence in pediatric nursing and its education: A systematic review.

Journal of pediatric nursing Mar 26, 2026

BACKGROUND: Artificial intelligence (AI) transforms healthcare delivery by improving patient outcomes and operational efficiencies. In pediatric nursing, AI meets the unique needs of children through family-centered care approaches that leverage mach... read more

Internal and external validation of a machine learning algorithm to detect preeclampsia-related adverse outcomes in high-risk pregnancies.

Pregnancy hypertension Mar 26, 2026

OBJECTIVES: This study aimed to refine an existing machine learning (ML) algorithm for predicting preeclampsia-related adverse outcomes and to assess its generalizability and predictive performance through internal validation in a German cohort and e... read more

Artificial Intelligence Medical Compendium