AI Medical Compendium

Peptide-protein docking: from physics-based models to generative intelligence.

Chemical communications (Cambridge, England) Mar 24, 2026

Peptide-protein interactions (PepPIs) play a pivotal role in cellular signaling and regulation, representing a significant category of therapeutic agents. However, determining peptide-protein complex structures by experiment is costly and often chall... read more

Harnessing the gut microbiota in extra-intestinal cancers: from causal evidence to immunotherapy strategies.

Immunotherapy Mar 24, 2026

The gut microbiota (GM) has emerged as a key modulator of cancer development and therapeutic response beyond the gastrointestinal tract. In extra-intestinal cancers, GM composition influences oncogenesis, with specific microbial taxa and their metabo... read more

CT-Based Automated Segmentation and Recurrence Prediction in Chronic Subdural Hematoma: A Dual-Label Multicenter Study.

Journal of neurotrauma Mar 24, 2026

Chronic subdural hematoma (CSDH) frequently recurs after burr-hole surgery, yet most prior imaging studies have focused primarily on hematoma and have not addressed the biomechanical effects of brain compression, which may play an important role in r... read more

Reimagining Brain Drug Delivery: Mechanistic and Translational Advances in Carbon Nanotube Nanomedicine.

Journal of applied toxicology : JAT Mar 24, 2026

Neurological and neurodegenerative disorders (NDDs) present ongoing therapeutic challenges attributed to the structural complexity of the central nervous system (CNS) and the restrictive properties of the blood-brain barrier (BBB), which inhibit the ... read more

A MULTIMODAL STOOL RNA, FIT AND MACHINE LEARNING CONCEPT FOR DETECTION OF ADVANCED PRECANCEROUS LESIONS AND COLORECTAL CANCER.

Cancer prevention research (Philadelphia, Pa.) Mar 24, 2026

Accurate and effective early detection of colorectal cancer (CRC) and advanced precancerous lesions (APLs) is still a challenge. The purpose of this study was to evaluate the clinical performance of a novel, non-invasive multimodal stool RNA test (mm... read more

A deep learning system for diagnosis of rheumatoid arthritis on digital hand photographs.

BMC rheumatology Mar 24, 2026

Integrated single-cell and bulk transcriptomic analysis identifies epithelial cell-related biomarkers and immune subtypes in focal segmental glomerulosclerosis.

International urology and nephrology Mar 24, 2026

BACKGROUND: Focal segmental glomerulosclerosis (FSGS) is a major cause of nephrotic syndrome and chronic kidney disease, characterized by podocyte injury and glomerular scarring. Its heterogeneity complicates early diagnosis and treatment. METHODS: W... read more

Innovative applications of artificial intelligence technology in pharmacometrics.

European journal of clinical pharmacology Mar 24, 2026

Boosting foundation models for rare eye disease diagnosis via a multimodal text-to-image generative framework.

NPJ digital medicine Mar 24, 2026

The rising prevalence of vision-threatening retinal diseases poses a significant burden on the global healthcare systems. Though deep learning (DL) techniques offer promising avenues for improving diagnostic efficiency, data scarcity and imbalance is... read more

Comparative evaluation of multimodal large language models for diagnostic accuracy in pediatric electrocardiography: a prospective comparative diagnostic accuracy study.

European journal of pediatrics Mar 24, 2026

UNLABELLED: We evaluated three multimodal LLMs, ChatGPT (GPT-5.2), Gemini 3, and Microsoft Copilot, in pediatric ECG interpretation, focusing on clinically significant abnormalities and emergency arrhythmias with likelihood ratios as primary outcome ... read more

Artificial Intelligence Medical Compendium