The goal of this review is to trace the history of refractive correction, from the earliest optical devices to modern refractive surgical techniques. Following the invention of spectacles in the Middle Ages, the first corneal procedures, such as Sato... read more
Corneal neovascularization (CNV) is a frequent complication of many ocular surface diseases and represents a major threat to corneal transparency, visual function, and corneal graft survival. Accurate characterization, longitudinal monitoring, and as... read more
The discovery of antibiotics transformed modern medicine and extended the average human lifespan by decades. However, the initial golden era of antibiotic discovery has significantly waned, a decline aggravated by the relentless evolution of drug res... read more
BACKGROUND: Breast cancer-related lymphedema is a frequent and debilitating complication. Early identification of high-risk individuals is critical, yet conventional risk models rarely incorporate systemic inflammatory status. METHODS: In this prospe... read more
Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental condition affecting mood, anxiety, learning, and sleep. Electroencephalogram (EEG) signals assist diagnosis, but challenges include complexity, nonlinearity, non-stationarity, ov... read more
INTRODUCTION: The advancement of AI-assisted oral disease diagnosis critically relies on the availability of annotated, high-quality datasets and resilient deep learning architectures. Nevertheless, progress in this domain has been impeded by the sca... read more
BACKGROUND: Coronal plane alignment of the knee (CPAK) categorizes knee phenotypes according to joint line obliquity (JLO) and the arithmetic hip‒knee‒ankle angle (aHKA). CPAK is traditionally measured via long leg radiographs, but recently other mod... read more
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
Mar 24, 2026
OBJECTIVES: To estimate the impact of a continuous dose reduction and quality improvement program on radiation-induced cancer risk in adult computed tomography (CT). METHODS: Between 2016 and 2022, the retrospective cohort study involved four phases:... read more
The 5' untranslated region (5' UTR) of messenger RNAs (mRNAs) plays a central role in regulating protein synthesis initiation, particularly through the Kozak sequence and upstream open reading frames (uORFs). Genetic variants within these regulatory ... read more
BACKGROUND: While artificial intelligence (AI)-assisted diagnostic software holds promise for improving diagnostic efficiency and reducing disparities in health care delivery, its effective implementation in lower-tier health care settings remains li... read more
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