Transformer-based Genomic Language Models (GLMs) have achieved strong performance across diverse genomic prediction tasks. However, their tendency toward overconfident predictions---particularly on noisy or unfamiliar data---limits reliability. In ge... read more
Protein function annotation is fundamental to understanding biological mechanisms, designing therapeutics, and advancing biomedical research. Current computational methods either rely on shallow sequence similarity or treat function prediction as iso... read more
Homeostatic mechanisms protect synapses from destabilizing challenges throughout an organism's lifespan, ensuring stable yet flexible neural network activity. To delineate the molecular basis of presynaptic homeostatic potentiation (PHP), we conducte... read more
Background: Prospective stroke registries have advanced our understanding of cerebrovascular disease, yet most reduce neuroimaging to categorical variables, forfeiting the multidimensional information inherent in clinical imaging. We describe the CRC... read more
The opioid crisis has severely impacted Ohio, with overdose death rates surpassing national averages and disproportionately affecting rural and Appalachian regions. Accurately predicting county-level opioid overdose deaths (OD) is critical for timely... read more
Frontier language models are widely used for health-related queries, yet aggregate benchmark scores do not capture safety implications of errors. We applied the recent Nature Medicine triage benchmark across nine frontier models, comparing directiona... read more
Objective: To develop and validate a multivariable prediction model and clinically actionable risk score for vaginal birth after cesarean (VBAC) success using machine learning, and to integrate neonatal morbidity outcomes into a decision-analytic fra... read more
Systems powered by large language models are widely used for health information and advice, yet robust evidence for their safety and effectiveness in real-world clinical care remains lacking. Most existing studies evaluate general-purpose chatbots in... read more
India's national research capacity and infrastructure are unevenly distributed across states and union territories (UTs), contributing to geographic variation in academic publication output. We developed Indiapub, an open-access web application that ... read more
Fraud in the health landscape is an aggravating issue, with far-reaching consequences burdening the financial stability of the health industry and threatening the quality of medical care. It results from vulnerabilities within the current healthcare ... read more
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