The role of dissolved black carbon (DBC) as an extracellular electron transfer carrier in pharmaceutical biodegradation mechanisms, along with its redox efficiency and redox-active components, remains insufficiently understood. In this study, a miner... read more
International journal of biological macromolecules
Mar 18, 2026
The papain-like protease (PLpro) is a structurally conserved cysteine protease whose catalytic activity and regulatory functions are governed by a well-defined macromolecular architecture and a dynamically adaptable ligand-binding site. Understanding... read more
International journal of biological macromolecules
Mar 18, 2026
BACKGROUND: Enhancer-promoter interactions (EPIs) play a central role in transcriptional regulation, yet it remains an open challenge to identify which enhancers regulate which target genes. Although deep learning methods based on DNA sequences or ge... read more
International journal of biological macromolecules
Mar 18, 2026
Antithyroid drugs, while essential for the management of hyperthyroidism, can induce adverse reactions detrimental to patient health. Therefore, developing a rapid, quantitative method for monitoring therapeutic drug levels in blood is critical for t... read more
Biochimica et biophysica acta. Reviews on cancer
Mar 18, 2026
The advancement of mRNA technology has rejuvenated the cancer treatment immunotherapy field by providing a flexible and scalable platform to generate tumor-associated or patient-specific neoantigens, which induces strong cytotoxic and helper T-cell o... read more
PURPOSE: Digital cough screening for COVID-19 detection shows promise, but population differences in cough acoustics and screening accuracy require investigation. This study examined cough characteristics and COVID-19 screening performance in Lima, P... read more
Journal of molecular graphics & modelling
Mar 18, 2026
Quantitative prediction of aqueous solubility (logS) is of great importance; however, achieving high-accuracy modelling remains challenging due to the structural diversity of molecules and variations in the quality of experimental data. To improve th... read more
BACKGROUND/AIMS: Standard withdrawal time (SWT) is a recognized colonoscopy quality metric but may not capture mucosal examination quality. We developed an artificial intelligence (AI)-derived metric, effective withdrawal time (EWT), to quantify clea... read more
The British journal of psychiatry : the journal of mental science
Mar 18, 2026
Clinical prediction models use individual-level patient data to inform clinical decisions across medicine. However, few are currently used in psychiatry. Here, we examine the opportunities and challenges presented by the new generation of clinical pr... read more
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