Electronic health records (EHRs) contain rich multimodal data but remain underutilized for populating clinical registries due to the time and cost of manual abstraction. We developed an AI driven pipeline to automate data abstraction for variables in... read more
Facioscapulohumeral muscular dystrophy (FSHD) is caused by epigenetic dysregulation of the disease locus, leading to pathogenic misexpression of DUX4 in skeletal muscle. Thus, most FSHD therapeutic approaches target DUX4. Our previous study identifie... read more
Fluorescence-based calcium-imaging is a powerful tool for studying localized neuronal activity, including miniature Synaptic Calcium Transients, providing real-time insights into synaptic activity. These transients induce only subtle changes in the f... read more
The development of Artificial Intelligence (AI) presents novel opportunities for tackling complex marine resource management challenges. Among AI models, neural networks are a powerful class of tools capable of learning nonlocal and lagged patterns f... read more
Glycosyltransferases (GTs) are a large family of enzymes that catalyze the formation of glycosidic linkages between chemically diverse donor and acceptor molecules to regulate diverse cellular processes across all domains of life. Despite their impor... read more
Cerebral amyloid angiopathy (CAA) commonly co-occurs with Alzheimer's disease (AD), yet the molecular changes that accompany vascular beta-amyloid deposition in human tissue remain incompletely defined. Herein, we use a novel imaging approach that co... read more
Recurrent neural networks (RNNs) have proven to be highly successful in emulating human-like cognitive functions such as working memory. In recent years, RNNs are evolving to incorporate more biophysical realism to produce more plausible predictions ... read more
Antimicrobial resistance (AMR) in plant pathogenic bacteria poses a serious threat to global agriculture, necessitating the development of novel antibacterial agents targeting virulence mechanisms. This study presents an integrated bioinformatics-dri... read more
Predicting treatment response remains challenging in oncology, particularly given the growing diversity of therapeutic options. Despite efforts using gene expression signatures, or integrative multi-omics frameworks, robust and interpretable biomarke... read more
De novo peptide design methods traditionally couple generation to 3D structure prediction, limiting throughput to seconds or hours per candidate. Here we present LigandForge, a discrete diffusion model that generates binding peptide sequences in a si... read more
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