Journal of computer-aided molecular design
Mar 13, 2026
Cancer is a complex disease characterised by the unregulated growth of abnormal cells. The intracellular signaling pathway, specifically phosphatidylinositol 3-kinase (PI3K)/AKT, is reported to be mutated in various cancers, including colorectal, gas... read more
BACKGROUND: The integration of multimodal single-cell data enables comprehensive organ reference atlases, yet its impact remains largely unexplored, particularly in complex tissues. Using the kidney as an emblematic example of a complex organ, we per... read more
Statistical methods to identify Neanderthal ancestry in modern human genomes rest on varying assumptions and inputs. Nonetheless, most studies of introgression use only a single method to define Neanderthal ancestry. Due to a lack of "ground truth," ... read more
INTRODUCTION: Simulation-based training has emerged as a critical tool in the acquisition of robotic surgical skills, especially in urology, where procedures are highly complex and technology-intensive. My article evaluates current simulation modalit... read more
Androgen receptor (AR) modulation is a critical safety concern for environmental chemicals, including agrochemicals, due to its role in endocrine disruption. Existing public data sets for AR modulation are limited in size and diversity. Here, we repo... read more
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