PURPOSE: Repeat prostate biopsy prediction remains limited by small patient cohorts that constrain artificial intelligence application despite theoretical advantages in capturing complex clinical patterns. This study develops and validates a meta-lea... read more
BACKGROUND: Obesity is a major health concern linked to chronic conditions such as diabetes and cardiovascular disease. However, most neurological studies have focused on specific metabolic states, limiting understanding of how brain function changes... read more
Artificial intelligence (AI) promises to enhance breast cancer screening. Here we evaluated Google's mammography AI system (version 1.2) across two phases: a retrospective study using 115,973 mammograms from five National Health Service screening ser... read more
Artificial intelligence (AI) tools can improve breast screening performance but different screening sites have varying needs. Here the GEMINI prospective evaluation of 10,889 women, within one UK region, used both live AI integration and simulations ... read more
The impact of incorporating artificial intelligence (AI) into a double-read breast-screening workflow, including arbitration, is unclear. This retrospective study included 50,000 representative women from two NHS breast-screening centers. All the wom... read more
Population-level structural variant (SV) profiling is crucial in the era of pangenomes. However, identifying SVs from genome assemblies and pangenome graphs remains a substantial challenge. Here we present Swave, a sequence-to-image, deep learning-ba... read more
Aging clinical and experimental research
Mar 10, 2026
BACKGROUND: Daily physical activity (PA) has been gaining attention for the management and prevention of knee osteoarthritis (OA). AIMS: This study aimed to compare the effects of various hypothetical daily PA regimens on the incidence of knee replac... read more
Prenatal assessment of fetal cardiac function is crucial for predicting neonatal outcomes, yet manual echocardiographic measurements are labor-intensive and subjective. We developed a fully automated artificial intelligence (AI) workflow for estimati... read more
Oxidative stress (OS) is a hallmark of Alzheimer's disease (AD), yet the cell type-specific mechanisms remain unclear. We analyzed a single-cell RNA sequencing (scRNA-seq) dataset to assess OS-related features in AD. OS scores were calculated using m... read more
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