AI Medical Compendium

Endothelial SMAD1-MCAM axis facilitates sunitinib resistance and progression of clear cell renal cell carcinoma via LAMB1-ITGB1 signaling.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy Mar 10, 2026

Clear cell renal cell carcinoma (ccRCC) is characterized by high metastatic potential and frequent resistance to conventional therapies, highlighting the need for a deeper understanding of its tumor microenvironment. Here, we integrated single-cell R... read more

Establishing a relationship between iron-based blood measures and structural brain changes using neural networks in UK Biobank.

Medical image analysis Mar 10, 2026

BACKGROUND: Disturbance of iron homeostasis in both the brain and blood is linked to cognitive impairment and neurodegenerative diseases. Investigation of the associations between changes in blood measurements and the accompanying structural changes ... read more

PTCMIL: multiple instance learning via prompt token clustering for whole slide image analysis.

Medical image analysis Mar 10, 2026

Multiple Instance Learning (MIL) has achieved significant success in whole slide image (WSI) analysis. However, the complexity and heterogeneity in WSIs remain fundamental challenges for MIL problem due to the various information in each WSI. However... read more

Comparison of conventional formulas and machine learning models for estimating serum low-density lipoprotein cholesterol.

Practical laboratory medicine Mar 10, 2026

BACKGROUND: Accurate estimation of low-density lipoprotein cholesterol (LDL-C) is essential for cardiovascular risk assessment and monitoring. Because β-quantification is labor-intensive and impractical for routine use, several equations have been de... read more

Identifying risk profile for adolescent e-cigarette use: A sex-stratified machine learning analysis.

Drug and alcohol dependence reports Mar 10, 2026

INTRODUCTION: Recent studies show that young females now report higher e-cigarette use than males, reversing prior trends. While sex differences in use are documented, little is known about underlying risk profiles. This study applied a machine learn... read more

Functional customization of peptide linkers in fusion proteins through multimodal deep learning approach.

Synthetic and systems biotechnology Mar 10, 2026

Peptide linkers are critical modulators of function in fusion proteins, a foundational technology in modern bioengineering. However, the rational customization of linkers for specific applications remains challenging, hindered by an insufficient unde... read more

Target-enhanced double-pulse LIBS coupled with feature-fused CNN for mechanistic and interpretable coffee origin authentication.

Food chemistry: X Mar 10, 2026

Coffee geographical origin authentication is critical for mitigating economically motivated adulteration, yet rapid trace-element analysis in complex organic matrices remains a significant challenge. This study establishes a novel synergistic framewo... read more

Research on data-driven rapid nondestructive quality evaluation method, Calculus Bovis as an example.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Mar 10, 2026

To address the low accuracy of traditional methods for animal-derived products due to spatial heterogeneity and limited portable tools resolution. This study built a data-driven rapid non-destructive framework integrating portable near infrared, mult... read more

A bio-inspired spiking neural network with adaptive spatiotemporal filtering and depth-modulated synaptic plasticity for robust collision detection.

Neural networks : the official journal of the International Neural Network Society Mar 10, 2026

Achieving fast and robust collision detection on autonomous agents requires perceiving threats and issuing early warnings with minimal latency. Particularly suited for this, dynamic vision sensors (DVS) capture high-speed motion with microsecond temp... read more

Structural mining and engineering of metagenome-derived Cas12a orthologs expands the CRISPR genome editing and multiplex diagnostics toolkit.

Molecular therapy : the journal of the American Society of Gene Therapy Mar 10, 2026

CRISPR-Cas12a is a compact, RNA-guided nuclease widely deployed in genome editing and molecular diagnostics, yet its broader utility is limited by suboptimal cis-cleavage efficiency and incompletely defined trans-cleavage behavior. To overcome these ... read more

Artificial Intelligence Medical Compendium