Aging selectively degrades neuronal structure and function, yet the signals that actively preserve neuronal integrity over adult life remain incompletely defined. In Caenorhabditis elegans, the PVD sensory neuron develops progressive excessive higher... read more
Glycosylation is a critical post-translational modification, and its aberrant forms are potent disease biomarkers; however, the comprehensive, site-specific identification of all glycosites and glycoforms across an entire proteome remains prohibitive... read more
Xanthan gum is a widely used industrial polysaccharide employed as a thickening and stabilizing agent in food, pharmaceutical, and technological applications. Its biosynthesis involves membrane-associated glycosyltransferases that assemble the repeat... read more
Background: Pavlovian responding is a core component of behavior and can be measured via Pavlovian-instrumental transfer (PIT), where Pavlovian responses bias instrumental actions. Standard single-lever PIT paradigms, which assess responses using a s... read more
Magnetoencephalography (MEG) and electroencephalography (EEG) source imaging requires solving an ill-posed inverse problem for which numerous algorithms have been proposed over the past decades. However, these methods are scattered across different p... read more
Genotype-phenotype prediction plays a crucial role in identifying disease-causing single nucleotide polymorphisms and precision medicine. In this manuscript, we benchmark the performance of various machine/deep learning algorithms and polygenic risk ... read more
Uncovering the genetic architecture of quantitative traits is challenging because polygenic control yields small individual gene effects and because gene-gene and genotype-by-environment interactions add further complexity. To understand the genetic ... read more
The liver has a complex architecture composed of millions of lobules. Within these lobules, hepatocytes, the main hepatic cells, are organized in rows separated by blood capillaries known as sinusoids. These capillaries are lined by liver sinusoidal ... read more
Sight is one of the five senses essential to human experience, and the eyes are vital organs that require careful protection. These organs are also susceptible to a variety of diseases, some of which may develop without obvious external symptoms, nec... read more
Clinical research depends on high quality data that is standardized, accessible and interoperable. Yet evolving data standards over time and variations in their implementation hinder the secondary use of clinical trial datasets. Although individual s... read more
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