Objectives: To identify unique echocardiographic signatures associated with TTR+ carrier status preceding onset of cardiac amyloidosis. Background: Carrier status for the most common pathogenic TTR variant in the United States, Val142Ile (V142I), fou... read more
As of early 2026, over 115 million US adults (more than 1 in 3) have prediabetes, a condition with an annual conversion rate of 5%-10% to type 2 diabetes. Total diabetes (diagnosed and undiagnosed) affects approximately 40.1 million Americans, or 12%... read more
Accurate polyp segmentation from colonoscopy images is critical for colorectal cancer prevention, yet the generalization of deep learning models under domain shift remains insufficiently explored. We propose Boundary-Explicit Guided Attention U-Net (... read more
Background and aims Population screening for liver disease in high-risk groups is recommended. Community diagnosis of liver disease is a challenge due to the asymptomatic nature of disease until very advanced stages. Moreover, regional variation in t... read more
Background Predictive models employing machine learning algorithms are increasingly being used in clinical decision making, and improperly calibrated models can result in systematic harm. We sought to investigate the impact of class imbalance correct... read more
Rationale Autonomic dysfunction is a hallmark of sepsis pathophysiology, yet its quantification remains challenging. Multiscale entropy (MSE) derived from heart rate variability (HRV) offers a dynamic measure of physiological complexity and may serve... read more
Background: Large language models (LLMs) are increasingly deployed in medical contexts as patient-facing assistants, providing medication information, symptom triage, and health guidance. Understanding their robustness to adversarial inputs is critic... read more
Stress detection with wearable physiological sensors is vital in digital health and affective computing. Conventional machine learning techniques usually examine physiological signals separately, missing the intricate inter-signal connections involve... read more
Chromosomes are the carriers of genetic information. Further understanding their 3D structure can help reveal gene-regulatory mechanisms and cellular functions. However, high-resolution 3D structures are often missing due to the high cost and inheren... read more
Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial immune receptor genetically and functionally linked to Alzheimers disease (AD). VG-3927, the first clinical-stage small-molecule TREM2 agonist, has been proposed to function as ... read more
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