We developed an integrated platform combining high-throughput automated biofabrication, systematic patient-derived tissue experiments, and specialized artificial intelligence to enable patient-specific computational "digital twins" for thrombosis pre... read more
Leptospira is a highly diverse genus traditionally classified by serological assays into more than 30 serogroups and over 300 serovars. However, this classification system is often complex and inconsistent, as cross-reactions between antigens can lea... read more
A major challenge in biology is predicting how cells transition between states over time and how perturbations disrupt these transitions. Understanding such dynamics is critical for identifying interventions that reverse pathological programs or repr... read more
Alternative lengthening of telomeres (ALT) is a telomerase-independent pathway used by aggressive cancers to maintain their replicative immortality. Because ALT is absent from normal human cells, it is an appealing target for cancer therapy, but the ... read more
Optical, ultrasound, and optoacoustic localization microscopy based on microparticle tracking has enabled surpassing the resolution limits imposed by ultrasound diffraction and optical diffusion in tissues. However, its reliance on high-speed (kilohe... read more
Measuring the growth rate of filamentous fungi is an essential phenotype assay in fungal biology, enabling the comparison of nutrient-related fitness metrics across various isolates, species and genera. Conventional methods are time consuming and lab... read more
Recent advances in deep learning have enabled prediction of odorant perception from molecular structure, opening new avenues for odor classification. However, most existing models are limited to predicting percepts from fixed vocabularies and fail to... read more
Accurate estimation of enzyme kinetic parameters is essential for enzyme engineering and industrial biocatalysis, yet their experimental measurement remains labor-intensive and costly. Although machine learning offers an efficient alternative, existi... read more
Fermented foods are an ancient, near universal component of human dietary culture and are increasingly recognized for their health benefits. Bioactive peptides and biosynthetic gene clusters (BGCs) produced by microbes during fermentation have been s... read more
Most genetic variants contributing to complex diseases reside in the noncoding genome. While common variants uncovered by genome-wide association studies often fail to explain much of the observed heritability of these diseases, rare variants often h... read more
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