Sleep is an essential behavioral state that evolved early in animals, possibly with the advent of the nervous system. The complexity of sleep neural networks varies significantly across phylogeny, yet common signaling molecules exist. Stress-induced ... read more
The preprint ecosystem has expanded rapidly over the past decade, fundamentally altering science communication. Yet, the scholarly community's attitudes toward this shift remain underexplored. Through a large-scale survey of US and Canadian biomedica... read more
Proteins underpin essential biological functions across all kingdoms of life. The capacity to design novel proteins with tailored activities holds transformative potential for biotechnology, medicine, and sustainability. However, since protein functi... read more
Monitoring fish communities is essential for understanding biodiversity dynamics and coral reef ecosystem health. Underwater imaging provides a non-invasive and repeatable approach for such monitoring, yet analysis of large volumes of video data rema... read more
Accurate annotation of protein function is essential for understanding biological processes, yet this remains challenging for proteins lacking characterized homologs or belonging to underrepresented functional classes. Although machine learning appro... read more
Large language models and generative protein design promise to accelerate biotechnology, but it remains unclear whether they can engineer dynamic megasynth(et)ases whose activity depends on transient, context-specific domain interfaces. Nonribosomal ... read more
Background: The 2024 blood culture bottle shortage brought diagnostic resource allocation to the forefront, reflecting persistent, foundational challenges with low-value testing and empiric treatment approaches under clinical uncertainty. Objective: ... read more
Tumour typing from whole-genome sequencing is increasingly accurate, yet molecular subtyping from somatic variants remains challenging because of tumour heterogeneity and inconsistent clinical annotations. Here, we present Mutation-Attention Dual-Tas... read more
Clear cell renal cell carcinoma (ccRCC) is the leading cause of kidney cancer-related death, but how the tumor microenvironment shapes patient survival is not completely understood. Here, we describe the characterization of ccRCC tumor ecosystems fro... read more
Handheld ultrasound devices have revolutionized point-of-care diagnostics, but their effectiveness remains limited by operator dependency and the need for specialized training. This paper presents an intelligent guidance and diagnostic assistance sys... read more
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