Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by profound molecular heterogeneity and inconsistent responses to gemcitabine-based therapy. Although KRAS mutations are nearly ubiquitous, the broader RTK-RAS and MAPK... read more
Background: Artificial intelligence is increasingly embedded in healthcare delivery. Its legitimacy depends on institutional governance, not technical performance alone. Prior research has centered on clinicians and patients. Less attention has been ... read more
Epigenetic clocks estimate biological age from DNA methylation patterns at CpG sites, providing robust predictions of mortality and morbidity risk. "Blue zones"-regions of exceptional longevity-offer a unique opportunity to investigate how biological... read more
Early screening for glaucoma and diabetic retinopathy (DR) is critical to prevent irreversible vision loss, yet remains inaccessible to many underserved populations. However, AI models trained on hospital-grade fundus images often generalize poorly t... read more
Identification of early interventions to reduce/eliminate asthma - the most common chronic disease among children - could significantly reduce burden on the healthcare system. Large-scale asthma Exposome-Wide Association Studies (ExWAS) could identif... read more
Introduction Clinicians and patients are likely to increasingly use Large Language Models (LLMs) for diagnostic support. Use of LLMs mostly created in North America and Europe, could lead to a High-Income Country bias if used in Low- and Middle-Incom... read more
Introduction: Atrial fibrillation (AF), a common arrhythmia, is associated with impaired quality of life (QoL) and increased stroke risk and mortality. Clinical guidelines recommend leveraging digital technologies to support patient education and AF ... read more
Background: Health technology assessment (HTA) agencies issue reimbursement recommendations that determine patient access to new therapies. Predicting these outcomes would enable sponsors to optimize market access strategies and health systems to ant... read more
Background: Cardiovascular disease remains the leading cause of global morbidity and mortality. The original My Heart Counts smartphone application demonstrated the feasibility of large-scale, fully digital recruitment and trial conduct, but was limi... read more
Background: Cognitive decline and dementia represent major public health challenges in aging populations. Natural language processing (NLP)-augmented clinical decision support systems (CDSS) offer promising tools for early detection, yet causal evide... read more
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