Rare diseases affect over 300 million people worldwide, yet patients often endure years-long diagnostic delays that limit timely intervention and trial opportunities. Computational rare disease recognition (RDR) remains constrained by knowledge resou... read more
Summary Background Once the treatment starts, early prediction of treatment benefit and its correlation with overall survival (OS) remains challenging in metastatic castration-resistant prostate cancer (mCRPC). Existing prognostic models require long... read more
Computational growth and remodeling (G&R) models have been extentively used to investigate abdominal aortic aneurysm (AAA) progression and to support clinical decision-making. However, the development of robust predictive models is often limited by t... read more
Background: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline, memory impairment, and functional deterioration. Its complex pathogenesis involves amyloid plaques, tau tangles, neuroinflammation, and synaptic ... read more
Background: Nontyphoidal Salmonella enterica (NTS) is a major public-health threat in the United States of America (U.S.). Evaluating associations between serovars, exposure sources, and settings in multistate outbreaks can reveal the drivers of NTS ... read more
Trypanosoma cruzi infection remains a central, yet methodologically challenging step in Chagas disease research and early-stage drug discovery. Current approaches largely rely on manual microscopy-based counting or on genetically modified parasites, ... read more
The development and validation of prognostic and predictive biomarkers in breast cancer is limited by the availability of well-annotated datasets linking tumor molecular features to treatment response and survival outcomes. To address this need, we g... read more
Electron microscopy (EM) and advanced volume EM have extensive applications in deciphering cellular ultrastructures for life sciences. However, quality issues of EM images significantly impede the precise analysis and discovery of nanoscale biologica... read more
Background: N4-acetylcytidine (ac4C) modification plays a critical role in cancer development. Exploring ac4C modification in laryngeal squamous cell carcinoma (LSCC) may help elucidate its pathogenesis. Methods: LSCC-related datasets were obtained f... read more
The traditional drug discovery pipeline is severely bottlenecked by the need to design and execute bespoke biological assays for every new target and compound, which is both time-consuming and prohibitively expensive. While machine learning has accel... read more
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