AI Medical Compendium

An AI-based approach accelerates the discovery of protein-protein interaction modulators targeting NCS-1.

European journal of medicinal chemistry Mar 3, 2026

Drug repurposing is an efficient strategy to accelerate the identification of therapeutic compounds by finding new uses for existing drugs. Here, we leveraged artificial intelligence (AI) to optimize this process and discover protein-protein interact... read more

Development of an interpretable machine learning model-based online tool for risk identification of anxiety symptoms in Chinese older adults.

Journal of affective disorders Mar 3, 2026

BACKGROUND: As the population aging process has accelerated, anxiety symptoms (AS) among older adults have become a critical concern. In addition to developing an online computational tool to identify high-risk persons in community settings, this stu... read more

Shift to the core: Abnormal core-periphery global topography in unipolar and bipolar depression.

Journal of affective disorders Mar 3, 2026

This study explores the global signal topography of core and periphery brain networks in Major Depressive Disorder (MDD), Bipolar disorder (BD-Dep) and healthy controls (HC) using resting-state fMRI. In a sample of 140 depressed MDD and BD patients, ... read more

Bridging AI advancements with risk assessment needs: A journey towards effective use and regulatory acceptance.

Toxicology Mar 3, 2026

In recent years, the development of artificial intelligence (AI), including machine learning (ML) and deep learning (DL), has not only captured the attention of scientists, industry, and society due to its vast potential, but also sparked debates reg... read more

Autonomic and resting-state effective connectivity signatures of binge eating behavior.

Neuroscience Mar 3, 2026

Autonomic dysfunction, measured by heart rate variability (HRV) is implicated in the manifestation of binge eating (BE) behaviors. Aberrant resting-state functional connectivity among brain regions involved in reward processing, affect regulation, an... read more

Integration of multi-omics and machine learning to reveal the anti-osteoporosis effects of Hederagenin by inhibiting lipid peroxidation via the GPX4/p-STAT1/PTGS2 axis.

Biochemical pharmacology Mar 3, 2026

Osteoporosis (OP) is a multifactorial disease, leading to abnormal bone remodeling, requiring targeted therapeutic interventions. This study investigated the pharmacological effects of Hederagenin (Hed), a triterpenoid saponin, in ovariectomized (OVX... read more

Population-based clustering of co-occurring social determinants: An application of unsupervised machine learning.

Annals of epidemiology Mar 3, 2026

PURPOSE: This study aimed to develop a cluster-based measure of multiple co-occurring social determinants of health by applying unsupervised machine learning to a population-based cohort, offering a data-driven approach to organize complex social exp... read more

USEM: A Unified Model for Simultaneous Estimation of Multiple Nutrient Concentrations in Coastal Waters using Landsat 5/7/8 and Sentinel-2 imagery.

Environmental research Mar 3, 2026

Accurate estimation of nutrient concentrations is vital for monitoring coastal eutrophication but remains challenging due to the lack of direct spectral features of nutrients and the constraints of single-sensor observations. To address these issues,... read more

Host-focused immunity, metabolism, and diagnostic innovation for precision control of tuberculosis globally.

Life sciences Mar 3, 2026

Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), remains one of the deadliest infectious diseases worldwide. Despite advances in treatment and diagnostics, challenges such as multidrug resistance, inadequate vaccines, diagnostic gaps an... read more

AVATAR: AI Vision Analysis for Three-dimensional Action in Real-time.

Experimental neurobiology Mar 3, 2026

Artificial intelligence (AI) provides new opportunities for high-resolution behavioral analysis and automated, human-free experiments. Here we present AVATAR (AI Vision Analysis for Three-dimensional Action in Real-time). This AI-driven system recons... read more

Artificial Intelligence Medical Compendium