Backgrounds: Most rare coding variants in monogenic disease genes remain classified as Variants of Uncertain Significance (VUS), limiting their use in clinical care. Many variant classifications have been submitted to ClinVar, often with rich free-te... read more
Lung cancer is characterized by profound intratumoral and inter-patient heterogeneity, spanning histological subtypes, molecular landscapes, and the tumor microenvironment. While multi-omics integration is essential for capturing this complexity, lev... read more
Background: Placental growth and function are imperative for healthy fetal growth; data on placentas can inform research and clinical care. Measuring placental size after delivery should be easy, but current methods are hard to standardize and error ... read more
Background Generative artificial intelligence (GenAI) in healthcare may reduce administrative burden and enhance quality of care. Large language models (LLMs) can generate draft responses to patient messages using electronic health record (EHR) data.... read more
UNLABELLED: Deep learning (DL) has the potential to enable the prediction of gene mutations directly from routine histopathology slides in lung cancer. However, existing approaches have largely been limited to mutation-level prediction and have not a... read more
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Mar 2, 2026
The second Society of Nuclear Medicine and Molecular Imaging (SNMMI) AI Summit, organized by the SNMMI AI Task Force, took place in Bethesda, MD, on February 29-March 1, 2024. Bringing together various community members and stakeholders and following... read more
UNLABELLED: Understanding drug responses at the cellular level is essential for elucidating mechanisms of action and advancing preclinical drug development. Traditional dose-response models rely on simplified metrics, limiting their ability to quanti... read more
UNLABELLED: Circular RNAs (circRNA) are associated with crucial hallmarks of tumorigenesis. Select circRNAs contain circular open reading frames (cORF) and affect tumorigenesis through encoded small peptides. However, current circRNA detection approa... read more
Cold Spring Harbor perspectives in medicine
Mar 2, 2026
There is an urgent need to develop additional treatments for tuberculosis (TB) to complement the small panel of approved drugs and to devise shorter treatment regimens. Within the last 20 years, we have seen an increased focus on using cheminformatic... read more
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