Immune checkpoint inhibitors (ICIs) have transformed the advanced melanoma treatment landscape; however, a subset of patients achieve durable responses. Current biomarkers, such as PD-L1 expression and tumor mutational burden, offer limited predictiv... read more
Conventional sports anticipation studies primarily rely on hypothesis-testing paradigms that target predetermined cues. However, such approaches risk overlooking unanticipated sources of predictive information. This study addresses this limitation by... read more
We present a framework and a novel dataset for detecting loss of pulse cases using a smartwatch. Our methodology for gathering data involves inducing controlled pulse loss in the forearm within a clinical setting under medical supervision. To the bes... read more
OBJECTIVES: This study aimed to investigate the association of COX-2 gene polymorphisms with key clinical features of migraine, including headache onset, duration, severity, and associated symptoms such as depression and nausea. METHODS: A total of 1... read more
Annual review of chemical and biomolecular engineering
Feb 27, 2026
Polymer design is being reshaped by demands for low-carbon fabrication and bioactive/living function. We trace the bidirectional interface between microbes and polymers. First, we analyze how microbes synthesize polymers like polysaccharides, polyest... read more
Journal of chemical information and modeling
Feb 27, 2026
Zinc ions serve dual roles in proteins: as catalytic cofactors and as structural elements. Distinguishing these functional classes from sequence alone remains challenging, because both share similar coordination geometries. Here, we demonstrate that ... read more
Journal of chemical theory and computation
Feb 27, 2026
An electron-vibrational Hamiltonian fully encodes corresponding quantum dynamics; however, extracting the dynamics still relies on time and memory-consuming trajectory-based nonadiabatic molecular dynamics (NAMD) simulations, typically stochastic sur... read more
Metabolomics : Official journal of the Metabolomic Society
Feb 27, 2026
BACKGROUND: Metabolomic data offers insights into disease mechanisms, diagnostics, and therapeutic targets by analyzing metabolic profiles. In analyzing these profiles, traditional bioinformatic and statistical approaches, while valuable, often strug... read more
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