Objectives: to evaluate the prognostic role of the marker albumin-myosteatosis (MAM) in Caucasian patients with metastatic colorectal cancer. Material and methods: this study involved 55 consecutive Caucasian patients diagnosed with metastatic colore... read more
Allele-specific quantification of sequencing data, such as gene expression, allows for a causal investigation of how DNA sequence variations influence cis gene regulation. Current methods for analyzing allele-specific measurements for causal analysis... read more
Advances in automation, imaging, and artificial intelligence have enabled researchers to capture large volumes of high-quality plant data for understanding crop growth, stress, and genotype-by-environment interactions. While genomics has achieved rem... read more
Synthetic lethality (SL) offers a promising paradigm for targeted cancer therapy, yet experimental identification of SL gene pairs remains costly, context-dependent, and biased toward well-studied genes. Existing computational approaches often rely o... read more
Predicting how cells respond to chemical perturbations is one of the goals for building virtual cells, yet experimentally profiled compounds cover only a small fraction of this space. Existing models struggle to generalize to unprofiled compounds, as... read more
Abiotic stresses are primary constraints on global crop productivity, reducing yields by up to 80%. While traditional phenotypic sensing detects stress only after physiological symptoms emerge and often fails to discriminate specific stressor types, ... read more
The convergence of large language model-powered autonomous agent systems and single-cell biology promises a paradigm shift in biomedical discovery. However, existing biological agent systems, building upon single-agent architectures, are narrowly spe... read more
The spatial organization of microbial communities is a critical determinant of host-microbe interactions, yet species-level mapping remains challenging due to high 16S rRNA sequence homology and spectral crosstalk in multiplexed fluorescence in situ ... read more
Transcription factors recognise and bind specific DNA sequence patterns in promoters and enhancers thereby regulating gene expression. Variations in the DNA sequence of transcription factor binding sites (TFBSs) can alter gene regulation and may disr... read more
Pediatric asthma exacerbations are a frequent cause of emergency department (ED) visits and hospitalizations, yet accurate risk prediction remains limited and no consensus risk scores exist. Using UF Health electronic health records (EHRs) from 2011-... read more
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