PURPOSE: To develop a machine learning-based modeling approach for extracting elastic stiffness estimates from Ocular Response Analyzer (ORA) waveforms. DESIGN: Prospective observational cohort study with model training and testing using development ... read more
STUDY OBJECTIVE: Artificial Intelligence (AI) is being increasingly applied in medical education, yet its role in developing complex communication skills, such as breaking bad news, is less well defined. The Joint Royal Colleges of Physicians Trainin... read more
Older people living with falls and frailty are common in emergency attendances, admissions and functional decline. Artificial intelligence (AI) and machine learning (ML) are increasingly incorporated in risk prediction, service streamlining and re-en... read more
Cytology cell block specimens are essential diagnostic materials in patients with advanced-stage malignancy and often represent the only available substrate for therapeutic biomarker evaluation. Their ability to preserve tumor cells, capture high-gra... read more
Sub-visible particle analysis using flow imaging microscopy combined with deep learning has proven effective in identifying particle types, enabling the distinction of harmless components such as silicone oil from protein particles. However, the scar... read more
The accelerating shift in biomedical research toward human-relevant, ethical, and innovative methodologies has propelled the adoption of Non-animal models (NAMs) as vital alternatives to traditional animal models. This review examines the different t... read more
Accurately predicting the carbon dioxide (CO2) adsorption capacity of magnesium oxide (MgO)-based sorbents is crucial for advancing carbon capture technologies. This study develops an interpretable machine learning framework to address this challenge... read more
Cancer therapy is increasingly shaped by delivery platforms designed to overcome the limitations of conventional chemotherapy and radiotherapy. Among these, bacterial outer membrane vesicles (OMVs) have emerged as versatile nanocarriers with intrinsi... read more
Clinica chimica acta; international journal of clinical chemistry
Feb 26, 2026
Exosomes are nanosized extracellular vesicles enriched with proteins, lipids, and nucleic acids and are emerging as powerful mediators of intercellular communication with transformative potential for psychiatry. Their ability to cross the blood-brain... read more
For decades, psychiatric neuroimaging has searched for biomarkers of depression and other disorders, but they remain elusive in clinical practice. While the last five years have seen rapid progress, other large-scale correlative studies have found on... read more
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