The growing volume of clinical imaging and the emergence of artificial intelligence technologies present a unique opportunity to extract additional value from existing imaging data that would otherwise go unused, providing patients with health benefi... read more
PURPOSE: To evaluate the performance of a deep learning (DL) model in classifying diabetic retinopathy (DR) severity using fundus images with varying fields of view and to assess whether central retinal features alone reflect overall disease burden. ... read more
The T Cell Receptor (TCR) is a highly variable component of the T cell immune response that recognizes unique epitopes presented on MHC molecules (pMHC). Random genetic recombination limits the ability for sequence homology to predict epitope specifi... read more
Artificial intelligence (AI) has transformed prediction of protein structure and biomolecular interactions, yet modeling of allosteric regulation remains a persistent and unresolved challenge. We develop a dual explainable AI framework that systemati... read more
We investigated whether the plasma proteome distinguishes people with epilepsy who report central nervous system (CNS) side effects from antiseizure medications (ASMs) from those who do not. In 161 patients profiled using proximity extension assay-ba... read more
In recent years, high dimensional omics analyses have become more commonplace for investigating complex biological systems. Typically, these studies attempt to identify key biomolecules associated with a particular biological process. Often, machine ... read more
Quantifying biological aging is crucial for understanding functional decline before the onset of morbidity. While many accelerated aging and frailty measures based on clinical data exist for humans and several for rodent models of aging, there are fe... read more
Light-sheet fluorescence microscopy enables deep optical sectioning of large, cleared biological tissues. However, effective clearing of collagen-rich tissues remains a persistent technical challenge. Moreover, standardized workflows integrating thre... read more
Agent-based models of the tumor microenvironment (TME) traditionally rely on hand-coded rules that cannot generalize beyond their programmed logic. Here we present CellSwarm, a framework that replaces rule-based cell decision-making with large langua... read more
The spatial organization of the tumor immune microenvironment (TIME) drives hepatocellular carcinoma (HCC) prognosis but remains unquantifiable on routine H&E slides. Here, we present HCCExplorer, a deep learning framework that translates H&E into vi... read more
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.