Study Objectives Automated sleep staging underpins clinical sleep assessment and translational neuroscience, yet most data analyses work addresses human and animal data separately. We tested whether a seizure-oriented machine learning framework can b... read more
Differences in microbiome composition profoundly influence drug response, yet methods to model the metabolic interplay between tumors, microbes, and therapeutics remain limited. We present a generalizable framework combining machine learning and geno... read more
Common genetic variants contribute to risk for complex human diseases. However, despite thousands of associations, variants modulating disease risk and their functional impact remain largely unknown. This includes SARS-CoV-2 infection, where outcomes... read more
Introduction: Cardiovascular diseases (CVDs) are the leading cause of death globally, with rising burdens in Africa due to ageing populations, lifestyle changes, and poor risk factor control. Conventional risk scores developed in high-income settings... read more
Clinical deployment of foundation models requires decision policies that operate under explicit error budgets, such as a cap on false-positive clinical calls. Strong average accuracy alone does not guarantee safety: errors can concentrate among patie... read more
Medical oncology education faces a dual crisis: knowledge velocity that outpaces static curricula and large language model (LLM) risks hallucination and automation bias, that threaten the fidelity of AI assisted learning. We present Onco Shikshak (sh... read more
Background: Hosting large language models (LLMs) on premises can secure patient data but requires compact architectures to function on standard hardware. The impact of such constraints on the robustness of their representations for medical terminolog... read more
Background: Kidney volumetry derived from CT has been proposed as a surrogate of renal function in living kidney donor evaluation. However, clinical integration has been limited by reader-dependent workflows and semiautomatic methods susceptible to i... read more
Purpose: Castration-resistant prostate cancer (CRPC) is characterized by marked clinical heterogeneity and poor long-term survival, underscoring the need for tools that can rapidly and reliably individualize patient risk. While several prognostic mod... read more
Importance: Tracking and predicting seizure frequency in patients with epilepsy is important for prognostication and therapy management. Interictal spikes have been proposed as a biomarker of seizure burden, but their association with seizure frequen... read more
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